Renilla-luciferin 2-monooxygenase

From Wikipedia, the free encyclopedia

In enzymology, a Renilla-luciferin 2-monooxygenase (EC 1.13.12.5) is an enzyme that catalyzes the chemical reaction

Renilla luciferin + O₂ $\rightleftharpoons$ oxidized Renilla luciferin + CO₂ + hnu

Thus, the two substrates of this enzyme are Renilla luciferin and O₂, whereas its 3 products are oxidized Renilla luciferin, CO₂, and hn.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include Renilla-type luciferase, aequorin, and luciferase (Renilla luciferin).

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1QV0, 1QV1, 2PSD, 2PSE, 2PSF, 2PSH, and 2PSJ.

[edit] References

IUBMB entry for 1.13.12.5
BRENDA references for 1.13.12.5 (Recommended.)
PubMed references for 1.13.12.5
PubMed Central references for 1.13.12.5
Google Scholar references for 1.13.12.5
Cormier MJ, Hori K, Anderson JM (1974). "Bioluminescence in coelenterates". Biochim. Biophys. Acta. 346: 137–64. PMID 4154104.
Hori K, Anderson JM, Ward WW, Cormier MJ (1975). "Renilla luciferin as the substrate for calcium induced photoprotein bioluminescence. Assignment of luciferin tautomers in aequorin and mnemiopsin". Biochemistry. 14: 2371–6. doi:10.1021/bi00682a016. PMID 237531.
Shimomura O, Johnson FH (1975). "Chemical nature of bioluminescence systems in coelenterates". Proc. Natl. Acad. Sci. U. S. A. 72: 1546–9. doi:10.1073/pnas.72.4.1546. PMID 236561.
Charbonneau H, Cormier MJ (1979). "Ca2+-induced bioluminescence in Renilla reniformis. Purification and characterization of a calcium-triggered luciferin-binding protein". J. Biol. Chem. 254: 769–80. PMID 33174.
Anderson JM, Charbonneau H, Cormier MJ (1974). "Mechanism of calcium induction of Renilla bioluminescence Involvement of a calcium-triggered luciferin binding protein". Biochemistry. 13: 1195–200. doi:10.1021/bi00703a602. PMID 4149963.
Lorenz WW, McCann RO, Longiaru M, Cormier MJ (1991). "Isolation and expression of a cDNA encoding Renilla reniformis luciferase". Proc. Natl. Acad. Sci. U. S. A. 88: 4438–42. doi:10.1073/pnas.88.10.4438. PMID 1674607.