RELT

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Tumor necrosis factor receptor superfamily, member 19-like
Identifiers
Symbol(s) TNFRSF19L; FLJ14993; RELT
External IDs MGI: 2443373 HomoloGene: 13151
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 84957 320100
Ensembl ENSG00000054967 ENSMUSG00000008318
Uniprot Q969Z4 Q497Z8
Refseq NM_032871 (mRNA)
NP_116260 (protein)		 NM_177073 (mRNA)
NP_796047 (protein)
Location Chr 11: 72.77 - 72.79 Mb Chr 7: 100.72 - 100.74 Mb
Pubmed search [1] [2]

Tumor necrosis factor receptor superfamily, member 19-like, also known as TNFRSF19L, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like.

[edit] Further reading

  • Polek TC, Talpaz M, Spivak-Kroizman TR (2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis.". Biochem. Biophys. Res. Commun. 349 (3): 1016-24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202. 
  • Bossen C, Ingold K, Tardivel A, et al. (2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.". J. Biol. Chem. 281 (20): 13964-71. doi:10.1074/jbc.M601553200. PMID 16547002. 
  • Cusick JK, Xu LG, Bin LH, et al. (2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.". Biochem. Biophys. Res. Commun. 340 (2): 535-43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sica GL, Zhu G, Tamada K, et al. (2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB.". Blood 97 (9): 2702-7. PMID 11313261. 
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