REG3A

From Wikipedia, the free encyclopedia

Regenerating islet-derived 3 alpha

PDB rendering based on 1uv0.

Available structures: 1uv0, 2go0

Identifiers

Symbol(s)

REG3A; PAP; HIP; INGAP; PAP-H; PAP1; PBCGF; REG-III; REG3

External IDs

OMIM: 167805 MGI: 97478 HomoloGene: 49257

Gene ontology
Molecular Function:	• sugar binding
Cellular Component:	• extracellular space • soluble fraction • cytoplasm
Biological Process:	• acute-phase response • inflammatory response • heterophilic cell adhesion • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002580 (mRNA)
NP_002571 (protein)

NM_011036 (mRNA)
NP_035166 (protein)

Location

Chr 2: 79.24 - 79.24 Mb

n/a

Pubmed search

[1]

[2]

Regenerating islet-derived 3 alpha, also known as REG3A, is a human gene.^[1]

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.^[1]

[edit] References

^ ^a ^b Entrez Gene: REG3A regenerating islet-derived 3 alpha.

[edit] Further reading

Lasserre C, Christa L, Simon MT, et al. (1992). "A novel gene (HIP) activated in human primary liver cancer.". Cancer Res. 52 (18): 5089-95. PMID 1325291.
Orelle B, Keim V, Masciotra L, et al. (1993). "Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases.". J. Clin. Invest. 90 (6): 2284-91. PMID 1469087.
Itoh T, Teraoka H (1993). "Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP).". Biochim. Biophys. Acta 1172 (1-2): 184-6. PMID 7679928.
Itoh T, Sawabu N, Motoo Y, et al. (1995). "The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons.". Gene 155 (2): 283-7. PMID 7721106.
Lasserre C, Simon MT, Ishikawa H, et al. (1994). "Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer.". Eur. J. Biochem. 224 (1): 29-38. PMID 8076648.
Dusetti NJ, Frigerio JM, Fox MF, et al. (1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene.". Genomics 19 (1): 108-14. doi:10.1006/geno.1994.1019. PMID 8188210.
Christa L, Carnot F, Simon MT, et al. (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells.". Am. J. Physiol. 271 (6 Pt 1): G993-1002. PMID 8997243.
Rafaeloff R, Pittenger GL, Barlow SW, et al. (1997). "Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters.". J. Clin. Invest. 99 (9): 2100-9. PMID 9151782.
Bödeker H, Keim V, Fiedler F, et al. (2000). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha.". Mol. Cell Biol. Res. Commun. 2 (3): 150-4. doi:10.1006/mcbr.1999.0166. PMID 10662590.
Graf R, Schiesser M, Scheele GA, et al. (2001). "A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation.". J. Biol. Chem. 276 (24): 21028-38. doi:10.1074/jbc.M010717200. PMID 11278730.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Simon MT, Pauloin A, Normand G, et al. (2003). "HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway.". FASEB J. 17 (11): 1441-50. doi:10.1096/fj.02-1013com. PMID 12890698.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lieu HT, Batteux F, Simon MT, et al. (2005). "HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice.". Hepatology 42 (3): 618-26. doi:10.1002/hep.20845. PMID 16116631.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin.". Science 313 (5790): 1126-30. doi:10.1126/science.1127119. PMID 16931762.
Ho MR, Lou YC, Lin WC, et al. (2006). "Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation.". J. Biol. Chem. 281 (44): 33566-76. doi:10.1074/jbc.M604513200. PMID 16963458.