RDH11

From Wikipedia, the free encyclopedia

Retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

Identifiers

RDH11; ARSDR1; CGI-82; FLJ32633; HCBP12; MDT1; PSDR1; RALR1; SCALD

External IDs

OMIM: 607849 MGI: 102581 HomoloGene: 69201

Gene ontology
Molecular Function:	• retinol dehydrogenase activity • oxidoreductase activity
Cellular Component:	• intracellular • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• metabolic process • retinol metabolic process • photoreceptor cell maintenance

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016026 (mRNA)
NP_057110 (protein)

XM_991992 (mRNA)
XP_997086 (protein)

Location

Chr 14: 67.21 - 67.23 Mb

Chr 12: 80.09 - 80.11 Mb

Pubmed search

[1]

[2]

Retinol dehydrogenase 11 (all-trans/9-cis/11-cis), also known as RDH11, is a human gene.^[1]

RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases, is expressed at high levels in prostate epithelium, and its expression is regulated by androgens.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis).

[edit] Further reading

Hara T, Harada N, Mitsui H, et al. (1994). "Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line.". Blood 84 (1): 189–99. PMID 8018917.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Lin B, White JT, Ferguson C, et al. (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium.". Cancer Res. 61 (4): 1611–8. PMID 11245473.
Kedishvili NY, Chumakova OV, Chetyrkin SV, et al. (2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).". J. Biol. Chem. 277 (32): 28909–15. doi:10.1074/jbc.M202588200. PMID 12036956.
Haeseleer F, Jang GF, Imanishi Y, et al. (2003). "Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.". J. Biol. Chem. 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMID 12226107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li K, Wang L, Cheng J, et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.". World J. Gastroenterol. 9 (2): 300–3. PMID 12532453.
Belyaeva OV, Stetsenko AV, Nelson P, Kedishvili NY (2004). "Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines.". Biochemistry 42 (50): 14838–45. doi:10.1021/bi035288u. PMID 14674758.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kasus-Jacobi A, Birch DG, Anderson RE (2007). "Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11.". Adv. Exp. Med. Biol. 572: 505–11. PMID 17249616.
Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes.". BMC Genomics 8: 42. doi:10.1186/1471-2164-8-42. PMID 17286855.