RBM9

From Wikipedia, the free encyclopedia

RNA binding motif protein 9

PDB rendering based on 2cq3.

Available structures: 2cq3, 2err

Identifiers

Symbol(s)

RBM9; HRNBP2; RTA

External IDs

MGI: 1933973 HomoloGene: 49375

Gene ontology
Molecular Function:	• nucleotide binding • transcription corepressor activity • RNA binding • transcription factor binding
Cellular Component:	• nucleus
Biological Process:	• RNA metabolic process • negative regulation of transcription • estrogen receptor signaling pathway • regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001031695 (mRNA)
NP_001026865 (protein)

NM_053104 (mRNA)
NP_444334 (protein)

Location

Chr 22: 34.47 - 34.75 Mb

Chr 15: 76.91 - 77.13 Mb

Pubmed search

[1]

[2]

RNA binding motif protein 9, also known as RBM9, is a human gene.^[1]

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: RBM9 RNA binding motif protein 9.

[edit] Further reading

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Lieberman AP, Friedlich DL, Harmison G, et al. (2001). "Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1.". Biochem. Biophys. Res. Commun. 282 (2): 499-506. doi:10.1006/bbrc.2001.4617. PMID 11401487.
Norris JD, Fan D, Sherk A, McDonnell DP (2002). "A negative coregulator for the human ER.". Mol. Endocrinol. 16 (3): 459-68. PMID 11875103.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27-36. doi:10.1101/gr.695703. PMID 12529303.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Underwood JG, Boutz PL, Dougherty JD, et al. (2005). "Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.". Mol. Cell. Biol. 25 (22): 10005-16. doi:10.1128/MCB.25.22.10005-10016.2005. PMID 16260614.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Ponthier JL, Schluepen C, Chen W, et al. (2006). "Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16.". J. Biol. Chem. 281 (18): 12468-74. doi:10.1074/jbc.M511556200. PMID 16537540.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.