RBM8A

From Wikipedia, the free encyclopedia

RNA binding motif protein 8A

PDB rendering based on 1p27.

Available structures: 1p27, 2hyi, 2j0q, 2j0s

Identifiers

Symbol(s)

RBM8A; BOV-1A; BOV-1B; BOV-1C; MDS014; RBM8; RBM8B; Y14; ZNRP; ZRNP1

External IDs

OMIM: 605313 MGI: 1913129 HomoloGene: 3744

Gene ontology
Molecular Function:	• nucleotide binding • mRNA binding • protein binding
Cellular Component:	• nucleus • spliceosome • cytoplasm
Biological Process:	• mRNA catabolic process, nonsense-mediated decay • mRNA processing • transport • biological_process • RNA splicing • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_005105 (mRNA)
NP_005096 (protein)

NM_025875 (mRNA)
NP_080151 (protein)

Location

Chr 1: 144.22 - 144.22 Mb

n/a

Pubmed search

[1]

[2]

RNA binding motif protein 8A, also known as RBM8A, is a human gene.

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.^[1]

[edit] References

^ Entrez Gene: RBM8A RNA binding motif protein 8A.

[edit] Further reading

Wilson KF, Fortes P, Singh US, et al. (1999). "The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction.". J. Biol. Chem. 274 (7): 4166–73. PMID 9933612.
Zhao XF, Nowak NJ, Shows TB, Aplan PD (2000). "MAGOH interacts with a novel RNA-binding protein.". Genomics 63 (1): 145–8. doi:10.1006/geno.1999.6064. PMID 10662555.
Conklin DC, Rixon MW, Kuestner RE, et al. (2000). "Cloning and gene expression of a novel human ribonucleoprotein.". Biochim. Biophys. Acta 1492 (2-3): 465–9. PMID 11004516.
Salicioni AM, Xi M, Vanderveer LA, et al. (2001). "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor.". Genomics 69 (1): 54–62. doi:10.1006/geno.2000.6315. PMID 11013075.
Kataoka N, Yong J, Kim VN, et al. (2000). "Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm.". Mol. Cell 6 (3): 673–82. PMID 11030346.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2001). "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.". EMBO J. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMID 11118221.
Mingot JM, Kostka S, Kraft R, et al. (2001). "Importin 13: a novel mediator of nuclear import and export.". EMBO J. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMID 11447110.
Kim VN, Kataoka N, Dreyfuss G (2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.". Science 293 (5536): 1832–6. doi:10.1126/science.1062829. PMID 11546873.
Lykke-Andersen J, Shu MD, Steitz JA (2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.". Science 293 (5536): 1836–9. doi:10.1126/science.1062786. PMID 11546874.
Hachet O, Ephrussi A (2002). "Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.". Curr. Biol. 11 (21): 1666–74. PMID 11696323.
Faurholm B, Millar RP, Katz AA (2002). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci.". Genomics 78 (1-2): 15–8. doi:10.1006/geno.2001.6650. PMID 11707068.
Kataoka N, Diem MD, Kim VN, et al. (2002). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.". EMBO J. 20 (22): 6424–33. doi:10.1093/emboj/20.22.6424. PMID 11707413.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Okubo K, Mitani H, Naruse K, et al. (2002). "Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes.". Biochem. Biophys. Res. Commun. 293 (1): 327–31. doi:10.1016/S0006-291X(02)00161-4. PMID 12054603.
Lejeune F, Ishigaki Y, Li X, Maquat LE (2002). "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.". EMBO J. 21 (13): 3536–45. doi:10.1093/emboj/cdf345. PMID 12093754.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gehring NH, Neu-Yilik G, Schell T, et al. (2003). "Y14 and hUpf3b form an NMD-activating complex.". Mol. Cell 11 (4): 939–49. PMID 12718880.
Fribourg S, Gatfield D, Izaurralde E, Conti E (2003). "A novel mode of RBD-protein recognition in the Y14-Mago complex.". Nat. Struct. Biol. 10 (6): 433–9. doi:10.1038/nsb926. PMID 12730685.
Lau CK, Diem MD, Dreyfuss G, Van Duyne GD (2004). "Structure of the Y14-Magoh core of the exon junction complex.". Curr. Biol. 13 (11): 933–41. PMID 12781131.