RBM17

From Wikipedia, the free encyclopedia

RNA binding motif protein 17

Identifiers

RBM17; MGC14439; SPF45

External IDs

OMIM: 606935 MGI: 1924188 HomoloGene: 13162

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding
Cellular Component:	• intracellular • nucleus • spliceosome
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032905 (mRNA)
NP_116294 (protein)

NM_152824 (mRNA)
NP_690037 (protein)

Location

Chr 10: 6.17 - 6.2 Mb

Chr 2: 11.5 - 11.52 Mb

Pubmed search

[1]

[2]

RNA binding motif protein 17, also known as RBM17, is a human gene.^[1]

[edit] References

^ Entrez Gene: RBM17 RNA binding motif protein 17.

[edit] Further reading

Graveley BR (2002). "Sex, AGility, and the regulation of alternative splicing.". Cell 109 (4): 409-12. PMID 12086596.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46-50. doi:10.1038/1700. PMID 9731529.
Lallena MJ, Chalmers KJ, Llamazares S, et al. (2002). "Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.". Cell 109 (3): 285-96. PMID 12015979.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sampath J, Long PR, Shepard RL, et al. (2003). "Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.". Am. J. Pathol. 163 (5): 1781-90. PMID 14578179.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Perry WL, Shepard RL, Sampath J, et al. (2005). "Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.". Cancer Res. 65 (15): 6593-600. doi:10.1158/0008-5472.CAN-03-3675. PMID 16061639.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chaouki AS, Salz HK (2007). "Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair.". PLoS Genet. 2 (12): e178. doi:10.1371/journal.pgen.0020178. PMID 17154718.
Corsini L, Bonnal S, Bonna S, et al. (2007). "U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.". Nat. Struct. Mol. Biol. 14 (7): 620-9. doi:10.1038/nsmb1260. PMID 17589525.