RBBP6

From Wikipedia, the free encyclopedia

Retinoblastoma binding protein 6

PDB rendering based on 2c7h.

Available structures: 2c7h

Identifiers

Symbol(s)

RBBP6; DKFZp686P0638; DKFZp761B2423; MY038; P2P-R; RBQ-1

External IDs

OMIM: 600938 MGI: 894835 HomoloGene: 5039

Gene ontology
Molecular Function:	• nucleic acid binding • ubiquitin-protein ligase activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• ubiquitin ligase complex • nucleus
Biological Process:	• regulation of progression through cell cycle • protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006910 (mRNA)
NP_008841 (protein)

NM_011247 (mRNA)
NP_035377 (protein)

Location

Chr 16: 24.46 - 24.61 Mb

Chr 7: 122.76 - 122.77 Mb

Pubmed search

[1]

[2]

Retinoblastoma binding protein 6, also known as RBBP6, is a human gene.^[1]

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: RBBP6 retinoblastoma binding protein 6.

[edit] Further reading

Sakai Y, Saijo M, Coelho K, et al. (1996). "cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product.". Genomics 30 (1): 98-101. doi:10.1006/geno.1995.0017. PMID 8595913.
Simons A, Melamed-Bessudo C, Wolkowicz R, et al. (1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb.". Oncogene 14 (2): 145-55. doi:10.1038/sj.onc.1200825. PMID 9010216.
Gao S, Witte MM, Scott RE (2002). "P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity.". J. Cell. Physiol. 191 (2): 145-54. doi:10.1002/jcp.10084. PMID 12064457.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Yoshitake Y, Nakatsura T, Monji M, et al. (2005). "Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.". Clin. Cancer Res. 10 (19): 6437-48. doi:10.1158/1078-0432.CCR-04-0841. PMID 15475430.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Scott RE, White-Grindley E, Ruley HE, et al. (2005). "P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA.". J. Cell. Physiol. 204 (1): 99-105. doi:10.1002/jcp.20263. PMID 15617101.
Pugh DJ, Ab E, Faro A, et al. (2006). "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.". BMC Struct. Biol. 6: 1. doi:10.1186/1472-6807-6-1. PMID 16396680.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.