RAP1GDS1

From Wikipedia, the free encyclopedia

RAP1, GTP-GDP dissociation stimulator 1

Identifiers

RAP1GDS1; GDS1; MGC118859; MGC118861

External IDs

OMIM: 179502 MGI: 2385189 HomoloGene: 41422

Gene ontology
Molecular Function:	• GTPase activator activity • binding
Cellular Component:	• cellular_component
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_021159 (mRNA)
NP_066982 (protein)

NM_001040690 (mRNA)
NP_001035780 (protein)

Location

Chr 4: 99.4 - 99.58 Mb

Chr 3: 138.86 - 138.99 Mb

Pubmed search

[1]

[2]

RAP1, GTP-GDP dissociation stimulator 1, also known as RAP1GDS1, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1.

[edit] Further reading

Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21.". Oncogene 7 (2): 289-93. PMID 1549351.
Riess O, Epplen C, Siedlaczck I, Epplen JT (1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25.". Hum. Genet. 92 (6): 629-30. PMID 8262526.
Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase.". J. Biol. Chem. 271 (43): 27013-7. PMID 8900189.
Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms.". Oncogene 21 (15): 2425-32. doi:10.1038/sj.onc.1205306. PMID 11948427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.". J. Biol. Chem. 278 (25): 22412-7. doi:10.1074/jbc.M212036200. PMID 12690117.
Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.". Blood 103 (7): 2661-7. doi:10.1182/blood-2003-06-2154. PMID 14615375.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.