Randle cycle

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The Randle cycle is a metabolic process involving the competition of glucose and fatty acids for substrates.[1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance.[2][3]

It is named for Philip Randle, who described it in 1963.[4]

[edit] References

  1. ^ Bevilacqua S, Buzzigoli G, Bonadonna R, et al (1990). "Operation of Randle's cycle in patients with NIDDM". Diabetes 39 (3): 383–9. PMID 2307295. 
  2. ^ Shuldiner AR, McLenithan JC (2004). "Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again". J. Clin. Invest. 114 (10): 1414–7. doi:10.1172/JCI200423586. PMID 15545992. 
  3. ^ Delarue J, Magnan C (2007). "Free fatty acids and insulin resistance". Current opinion in clinical nutrition and metabolic care 10 (2): 142–8. doi:10.1097/MCO.0b013e328042ba90. PMID 17285001. 
  4. ^ Randle PJ, Garland PB, Hales CN, Newsholme EA (1963). "The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus". Lancet 1: 785–9. PMID 13990765. 
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