RANBP1

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RAN binding protein 1
PDB rendering based on 1k5d.
Available structures: 1k5d, 1k5g
Identifiers
Symbol(s) RANBP1; MGC88701
External IDs OMIM: 601180 MGI: 96269 HomoloGene: 21600
Orthologs
Human Mouse
Entrez 5902 19385
Ensembl n/a ENSMUSG00000005732
Uniprot n/a O08846
Refseq NM_002882 (mRNA)
NP_002873 (protein)		 NM_011239 (mRNA)
NP_035369 (protein)
Location n/a Chr 16: 18.15 - 18.16 Mb
Pubmed search [1] [2]

RAN binding protein 1, also known as RANBP1, is a human gene.[1]

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.[1]

[edit] References

  1. ^ a b Entrez Gene: RANBP1 RAN binding protein 1.

[edit] Further reading

  • Hayashi N, Yokoyama N, Seki T, et al. (1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.". Mol. Gen. Genet. 247 (6): 661–9. PMID 7616957. 
  • Bischoff FR, Krebber H, Smirnova E, et al. (1995). "Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.". EMBO J. 14 (4): 705–15. PMID 7882974. 
  • Ren M, Villamarin A, Shih A, et al. (1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.". Mol. Cell. Biol. 15 (4): 2117–24. PMID 7891706. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Coutavas E, Ren M, Oppenheim JD, et al. (1994). "Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.". Nature 366 (6455): 585–7. doi:10.1038/366585a0. PMID 8255297. 
  • Zolotukhin AS, Felber BK (1997). "Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.". J. Biol. Chem. 272 (17): 11356–60. PMID 9111043. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Kehlenbach RH, Dickmanns A, Kehlenbach A, et al. (1999). "A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.". J. Cell Biol. 145 (4): 645–57. PMID 10330396. 
  • Plafker K, Macara IG (2000). "Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.". Mol. Cell. Biol. 20 (10): 3510–21. PMID 10779340. 
  • Steggerda SM, Paschal BM (2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran.". J. Biol. Chem. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. PMID 10811801. 
  • Maynard TM, Haskell GT, Bhasin N, et al. (2002). "RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction.". Mech. Dev. 111 (1-2): 177–80. PMID 11804793. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Di Fiore B, Ciciarello M, Mangiacasale R, et al. (2004). "Mammalian RanBP1 regulates centrosome cohesion during mitosis.". J. Cell. Sci. 116 (Pt 16): 3399–411. doi:10.1242/jcs.00624. PMID 12840069. 
  • Seewald MJ, Kraemer A, Farkasovsky M, et al. (2003). "Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?". Mol. Cell. Biol. 23 (22): 8124–36. PMID 14585972. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bohlson SS, Zhang M, Ortiz CE, Tenner AJ (2005). "CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis.". J. Leukoc. Biol. 77 (1): 80–9. doi:10.1189/jlb.0504305. PMID 15459234. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. 
  • Takeda E, Hieda M, Katahira J, Yoneda Y (2006). "Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.". Cell Struct. Funct. 30 (2): 69–80. PMID 16428860. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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