RALY

From Wikipedia, the free encyclopedia

RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))

PDB rendering based on 1wf1.

Available structures: 1wf1

Identifiers

Symbol(s)

RALY; MGC117312; P542

External IDs

MGI: 97850 HomoloGene: 7216

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding
Cellular Component:	• nucleus • spliceosome • heterogeneous nuclear ribonucleoprotein complex
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007367 (mRNA)
NP_031393 (protein)

NM_023130 (mRNA)
NP_075619 (protein)

Location

Chr 20: 32.05 - 32.13 Mb

Chr 2: 154.48 - 154.56 Mb

Pubmed search

[1]

[2]

RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)), also known as RALY, is a human gene.^[1]

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.^[1]

[edit] References

^ ^a ^b Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)).

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F. "Phosphoproteomic analysis of the human pituitary.". Pituitary 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (1999). "Alternative processing of the human and mouse raly genes(1).". Biochim. Biophys. Acta 1447 (1): 107–12. PMID 10500250.
Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH (1997). "The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein.". J. Autoimmun. 10 (5): 447–54. doi:10.1006/jaut.1997.9996. PMID 9376072.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Vaughan JH, Valbracht JR, Nguyen MD, et al. (1995). "Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1.". J. Clin. Invest. 95 (3): 1306–15. PMID 7533788.