RALB

From Wikipedia, the free encyclopedia

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

Identifiers

External IDs

OMIM: 179551 MGI: 1927244 HomoloGene: 20632

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • GTP binding
Cellular Component:	• intracellular • membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002881 (mRNA)
NP_002872 (protein)

NM_022327 (mRNA)
NP_071722 (protein)

Location

Chr 2: 120.73 - 120.77 Mb

Chr 1: 121.3 - 121.33 Mb

Pubmed search

[1]

[2]

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein), also known as RALB, is a human gene.^[1]

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.^[1]

[edit] References

^ ^a ^b Entrez Gene: RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein).

[edit] Further reading

Hsieh CL, Swaroop A, Francke U (1990). "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein.". Somat. Cell Mol. Genet. 16 (4): 407–10. PMID 2120779.
Chardin P, Tavitian A (1989). "Coding sequences of human ralA and ralB cDNAs.". Nucleic Acids Res. 17 (11): 4380. PMID 2662142.
Jullien-Flores V, Dorseuil O, Romero F, et al. (1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.". J. Biol. Chem. 270 (38): 22473–7. PMID 7673236.
Jilkina O, Bhullar RP (1997). "Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets.". Biochim. Biophys. Acta 1314 (1-2): 157–66. PMID 8972729.
Ikeda M, Ishida O, Hinoi T, et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.". J. Biol. Chem. 273 (2): 814–21. PMID 9422736.
Sugihara K, Asano S, Tanaka K, et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation.". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID 11744922.
Clough RR, Sidhu RS, Bhullar RP (2002). "Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets.". J. Biol. Chem. 277 (32): 28972–80. doi:10.1074/jbc.M201504200. PMID 12034722.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chien Y, White MA (2004). "RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.". EMBO Rep. 4 (8): 800–6. doi:10.1038/sj.embor.embor899. PMID 12856001.
Hernández-Muñoz I, Benet M, Calero M, et al. (2003). "rgr oncogene: activation by elimination of translational controls and mislocalization.". Cancer Res. 63 (14): 4188–95. PMID 12874025.
Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions.". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sidhu RS, Clough RR, Bhullar RP (2005). "Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin.". J. Biol. Chem. 280 (23): 21933–41. doi:10.1074/jbc.M412966200. PMID 15817490.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chien Y, Kim S, Bumeister R, et al. (2006). "RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.". Cell 127 (1): 157–70. doi:10.1016/j.cell.2006.08.034. PMID 17018283.
Lim KH, O'Hayer K, Adam SJ, et al. (2007). "Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.". Curr. Biol. 16 (24): 2385–94. doi:10.1016/j.cub.2006.10.023. PMID 17174914.
Smith SC, Oxford G, Baras AS, et al. (2007). "Expression of ral GTPases, their effectors, and activators in human bladder cancer.". Clin. Cancer Res. 13 (13): 3803–13. doi:10.1158/1078-0432.CCR-06-2419. PMID 17606711.
Yin J, Pollock C, Tracy K, et al. (2007). "Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.". Mol. Cell. Biol. 27 (21): 7538–50. doi:10.1128/MCB.00955-07. PMID 17709381.