RALBP1

From Wikipedia, the free encyclopedia

RalA binding protein 1

Identifiers

RALBP1; RIP; RIP1; RLIP76

External IDs

OMIM: 605801 MGI: 108466 HomoloGene: 4940

Gene ontology
Molecular Function:	• GTPase activator activity • protein binding • ATPase activity • Ral GTPase binding • Rac GTPase activator activity • ATPase activity, coupled to movement of substances • Rac GTPase binding
Cellular Component:	• intracellular • membrane
Biological Process:	• transport • chemotaxis • signal transduction • small GTPase mediated signal transduction • regulation of GTPase activity • positive regulation of Cdc42 GTPase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006788 (mRNA)
NP_006779 (protein)

NM_009067 (mRNA)
NP_033093 (protein)

Location

Chr 18: 9.47 - 9.53 Mb

Chr 17: 65.75 - 65.78 Mb

Pubmed search

[1]

[2]

RalA binding protein 1, also known as RALBP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: RALBP1 ralA binding protein 1.

[edit] Further reading

Awasthi S, Sharma R, Singhal SS, et al. (2003). "RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics.". Drug Metab. Dispos. 30 (12): 1300-10. PMID 12433796.
Jullien-Flores V, Dorseuil O, Romero F, et al. (1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.". J. Biol. Chem. 270 (38): 22473-7. PMID 7673236.
Yamaguchi A, Urano T, Goi T, Feig LA (1998). "An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1.". J. Biol. Chem. 272 (50): 31230-4. PMID 9395447.
Ikeda M, Ishida O, Hinoi T, et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.". J. Biol. Chem. 273 (2): 814-21. PMID 9422736.
Iouzalen N, Camonis J, Moreau J (1998). "Identification and characterization in Xenopus of XsmgGDS, a RalB binding protein.". Biochem. Biophys. Res. Commun. 250 (2): 359-63. doi:10.1006/bbrc.1998.9336. PMID 9753634.
Suzuki J, Yamazaki Y, Li G, et al. (2000). "Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts.". Mol. Cell. Biol. 20 (13): 4658-65. PMID 10848592.
Jullien-Flores V, Mahé Y, Mirey G, et al. (2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.". J. Cell. Sci. 113 ( Pt 16): 2837-44. PMID 10910768.
Awasthi S, Cheng J, Singhal SS, et al. (2000). "Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.". Biochemistry 39 (31): 9327-34. PMID 10924126.
Sharma R, Singhal SS, Cheng J, et al. (2001). "RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes.". Arch. Biochem. Biophys. 391 (2): 171-9. doi:10.1006/abbi.2001.2395. PMID 11437348.
Singhal SS, Singhal J, Cheng J, et al. (2002). "Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes.". Acta Biochim. Pol. 48 (2): 551-62. PMID 11732624.
Matsuzaki T, Hanai S, Kishi H, et al. (2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway.". J. Biol. Chem. 277 (21): 19008-18. doi:10.1074/jbc.M112472200. PMID 11882656.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Singhal SS, Singhal J, Sharma R, et al. (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.". Int. J. Oncol. 22 (2): 365-75. PMID 12527936.
Awasthi S, Singhal SS, Singhal J, et al. (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.". Int. J. Oncol. 22 (4): 713-20. PMID 12632060.
Awasthi S, Singhal SS, Singhal J, et al. (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.". Int. J. Oncol. 22 (4): 721-32. PMID 12632061.
Rossé C, L'Hoste S, Offner N, et al. (2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.". J. Biol. Chem. 278 (33): 30597-604. doi:10.1074/jbc.M302191200. PMID 12775724.
Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions.". J. Biol. Chem. 278 (51): 51743-8. doi:10.1074/jbc.M308702200. PMID 14525976.
Gómez MI, Lee A, Reddy B, et al. (2004). "Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1.". Nat. Med. 10 (8): 842-8. doi:10.1038/nm1079. PMID 15247912.
Zhang H, Zhang R, Luo Y, et al. (2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.". J. Biol. Chem. 279 (43): 44955-65. doi:10.1074/jbc.M407617200. PMID 15310755.