RALA

From Wikipedia, the free encyclopedia

V-ral simian leukemia viral oncogene homolog A (ras related)

PDB rendering based on 1u8y.

Available structures: 1u8y, 1u8z, 1u90, 1uad, 1zc3, 1zc4, 2a78, 2a9k, 2bov

Identifiers

Symbol(s)

RALA; MGC48949; RAL

External IDs

OMIM: 179550 MGI: 1927243 HomoloGene: 3942

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • GTP binding
Cellular Component:	• intracellular • membrane
Biological Process:	• chemotaxis • signal transduction • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005402 (mRNA)
NP_005393 (protein)

XM_985790 (mRNA)
XP_990884 (protein)

Location

Chr 7: 39.63 - 39.71 Mb

Chr 13: 17.67 - 17.73 Mb

Pubmed search

[1]

[2]

V-ral simian leukemia viral oncogene homolog A (ras related), also known as RALA, is a human gene.^[1]

The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: RALA v-ral simian leukemia viral oncogene homolog A (ras related).

[edit] Further reading

Kinsella BT, Erdman RA, Maltese WA (1991). "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA.". J. Biol. Chem. 266 (15): 9786–94. PMID 1903399.
Polakis PG, Weber RF, Nevins B, et al. (1989). "Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets.". J. Biol. Chem. 264 (28): 16383–9. PMID 2550440.
Chardin P, Tavitian A (1989). "Coding sequences of human ralA and ralB cDNAs.". Nucleic Acids Res. 17 (11): 4380. PMID 2662142.
Rousseau-Merck MF, Bernheim A, Chardin P, et al. (1988). "The ras-related ral gene maps to chromosome 7p15-22.". Hum. Genet. 79 (2): 132–6. PMID 3292391.
Cantor SB, Urano T, Feig LA (1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases.". Mol. Cell. Biol. 15 (8): 4578–84. PMID 7623849.
Jullien-Flores V, Dorseuil O, Romero F, et al. (1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.". J. Biol. Chem. 270 (38): 22473–7. PMID 7673236.
Wang KL, Khan MT, Roufogalis BD (1997). "Identification and characterization of a calmodulin-binding domain in Ral-A, a Ras-related GTP-binding protein purified from human erythrocyte membrane.". J. Biol. Chem. 272 (25): 16002–9. PMID 9188503.
Luo JQ, Liu X, Hammond SM, et al. (1997). "RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1.". Biochem. Biophys. Res. Commun. 235 (3): 854–9. doi:10.1006/bbrc.1997.6793. PMID 9207251.
Ikeda M, Ishida O, Hinoi T, et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.". J. Biol. Chem. 273 (2): 814–21. PMID 9422736.
Vavvas D, Li X, Avruch J, Zhang XF (1998). "Identification of Nore1 as a potential Ras effector.". J. Biol. Chem. 273 (10): 5439–42. PMID 9488663.
Kim JH, Lee SD, Han JM, et al. (1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA.". FEBS Lett. 430 (3): 231–5. PMID 9688545.
Ohta Y, Suzuki N, Nakamura S, et al. (1999). "The small GTPase RalA targets filamin to induce filopodia.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2122–8. PMID 10051605.
Wang KL, Roufogalis BD (1999). "Ca2+/calmodulin stimulates GTP binding to the ras-related protein ral-A.". J. Biol. Chem. 274 (21): 14525–8. PMID 10329639.
Suzuki J, Yamazaki Y, Li G, et al. (2000). "Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts.". Mol. Cell. Biol. 20 (13): 4658–65. PMID 10848592.
de Bruyn KM, de Rooij J, Wolthuis RM, et al. (2000). "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.". J. Biol. Chem. 275 (38): 29761–6. doi:10.1074/jbc.M001160200. PMID 10889189.
Brymora A, Valova VA, Larsen MR, et al. (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.". J. Biol. Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615.
Sugihara K, Asano S, Tanaka K, et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation.". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID 11744922.
Clough RR, Sidhu RS, Bhullar RP (2002). "Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets.". J. Biol. Chem. 277 (32): 28972–80. doi:10.1074/jbc.M201504200. PMID 12034722.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Xu L, Frankel P, Jackson D, et al. (2003). "Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.". Mol. Cell. Biol. 23 (2): 645–54. PMID 12509462.