RAGE (gene)

From Wikipedia, the free encyclopedia

Renal tumor antigen

Identifiers

RAGE; MOK; RAGE1

External IDs

OMIM: 605762 MGI: 1347040 HomoloGene: 8062

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• cytoplasm
Biological Process:	• protein amino acid phosphorylation • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014226 (mRNA)
NP_055041 (protein)

NM_011973 (mRNA)
NP_036103 (protein)

Location

Chr 14: 101.76 - 101.84 Mb

Chr 12: 111.26 - 111.29 Mb

Pubmed search

[1]

[2]

Renal tumor antigen, also known as RAGE, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAGE renal tumor antigen.

[edit] Further reading

Gaugler B, Brouwenstijn N, Vantomme V, et al. (1996). "A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma.". Immunogenetics 44 (5): 323–30. PMID 8781117.
Miyata Y, Akashi M, Nishida E (1999). "Molecular cloning and characterization of a novel member of the MAP kinase superfamily.". Genes Cells 4 (5): 299–309. PMID 10421840.
Eichmüller S, Usener D, Jochim A, Schadendorf D (2003). "mRNA expression of tumor-associated antigens in melanoma tissues and cell lines.". Exp. Dermatol. 11 (4): 292–301. PMID 12190937.
Götte K, Usener D, Riedel F, et al. (2003). "Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes.". Acta Otolaryngol. 122 (5): 546–52. PMID 12206267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yan M, Ghorab Z, Nadji M (2004). "Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas.". Appl. Immunohistochem. Mol. Morphol. 11 (2): 113–5. PMID 12777992.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Miura J, Uchigata Y, Yamamoto Y, et al. (2004). "AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes.". J. Diabetes Complicat. 18 (1): 53–9. doi:10.1016/S1056-8727(02)00281-7. PMID 15019601.
Rudofsky G, Isermann B, Schilling T, et al. (2004). "A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes.". Exp. Clin. Endocrinol. Diabetes 112 (3): 135–41. doi:10.1055/s-2004-817822. PMID 15052533.
Uesaka T, Kageyama N (2004). "Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.". FEBS Lett. 573 (1-3): 147–54. doi:10.1016/j.febslet.2004.07.070. PMID 15327990.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bierhaus A, Haslbeck KM, Humpert PM, et al. (2005). "Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily.". J. Clin. Invest. 114 (12): 1741–51. doi:10.1172/JCI200418058. PMID 15599399.
Grunau C, Sanchez C, Ehrlich M, et al. (2005). "Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer.". Genes Chromosomes Cancer 43 (1): 11–24. doi:10.1002/gcc.20155. PMID 15704127.
dos Santos KG, Canani LH, Gross JL, et al. (2005). "The -374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes.". Mol. Genet. Metab. 85 (2): 149–56. doi:10.1016/j.ymgme.2005.02.010. PMID 15896660.
Oehlrich N, Devitt G, Linnebacher M, et al. (2005). "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma.". Int. J. Cancer 117 (2): 256–64. doi:10.1002/ijc.21200. PMID 15900605.
Dumitriu IE, Baruah P, Bianchi ME, et al. (2005). "Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells.". Eur. J. Immunol. 35 (7): 2184–90. doi:10.1002/eji.200526066. PMID 15915542.
Haslbeck KM, Friess U, Schleicher ED, et al. (2007). "The RAGE pathway in inflammatory myopathies and limb girdle muscular dystrophy.". Acta Neuropathol. 110 (3): 247–54. doi:10.1007/s00401-005-1043-3. PMID 15986224.
Ramprasad S, Radha V, Mathias RA, et al. (2007). "Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India.". Eye (London, England) 21 (3): 395–401. doi:10.1038/sj.eye.6702239. PMID 16440015.
Lindholm E, Bakhtadze E, Sjögren M, et al. (2007). "The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.". Diabetologia 49 (11): 2745–55. doi:10.1007/s00125-006-0412-3. PMID 16969646.
Dumitriu IE, Bianchi ME, Bacci M, et al. (2007). "The secretion of HMGB1 is required for the migration of maturing dendritic cells.". J. Leukoc. Biol. 81 (1): 84–91. doi:10.1189/jlb.0306171. PMID 17035340.