RAD1 homolog

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RAD1 homolog (S. pombe)
Identifiers
Symbol(s) RAD1; HRAD1; REC1
External IDs OMIM: 603153 MGI: 1316678 HomoloGene: 37695
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5810 19355
Ensembl ENSG00000113456 ENSMUSG00000022248
Uniprot O60671 Q9QWZ1
Refseq NM_002853 (mRNA)
NP_002844 (protein)		 NM_011232 (mRNA)
NP_035362 (protein)
Location Chr 5: 34.94 - 34.95 Mb Chr 15: 10.43 - 10.44 Mb
Pubmed search [1] [2]

RAD1 homolog (S. pombe), also known as RAD1, is a human gene.[1]

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: RAD1 RAD1 homolog (S. pombe).

[edit] Further reading

  • Bardwell AJ, Bardwell L, Johnson DK, Friedberg EC (1993). "Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains.". Mol. Microbiol. 8 (6): 1177-88. PMID 8361362. 
  • Parker AE, Van de Weyer I, Laus MC, et al. (1998). "A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease.". J. Biol. Chem. 273 (29): 18332-9. PMID 9660799. 
  • Udell CM, Lee SK, Davey S (1998). "HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene.". Nucleic Acids Res. 26 (17): 3971-6. PMID 9705507. 
  • Freire R, Murguía JR, Tarsounas M, et al. (1998). "Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.". Genes Dev. 12 (16): 2560-73. PMID 9716408. 
  • Bluyssen HA, van Os RI, Naus NC, et al. (1999). "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene.". Genomics 54 (2): 331-7. doi:10.1006/geno.1998.5582. PMID 9828137. 
  • Marathi UK, Dahlen M, Sunnerhagen P, et al. (1999). "RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene.". Genomics 54 (2): 344-7. doi:10.1006/geno.1998.5589. PMID 9828139. 
  • Volkmer E, Karnitz LM (1999). "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex.". J. Biol. Chem. 274 (2): 567-70. PMID 9872989. 
  • Dean FB, Lian L, O'Donnell M (1999). "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.". Genomics 54 (3): 424-36. doi:10.1006/geno.1998.5587. PMID 9878245. 
  • St Onge RP, Udell CM, Casselman R, Davey S (1999). "The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.". Mol. Biol. Cell 10 (6): 1985-95. PMID 10359610. 
  • Hang H, Lieberman HB (2000). "Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.". Genomics 65 (1): 24-33. doi:10.1006/geno.2000.6142. PMID 10777662. 
  • Cai RL, Yan-Neale Y, Cueto MA, et al. (2000). "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.". J. Biol. Chem. 275 (36): 27909-16. doi:10.1074/jbc.M000168200. PMID 10846170. 
  • Burtelow MA, Kaufmann SH, Karnitz LM (2000). "Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage.". J. Biol. Chem. 275 (34): 26343-8. doi:10.1074/jbc.M001244200. PMID 10852904. 
  • Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.". J. Biol. Chem. 275 (38): 29767-71. doi:10.1074/jbc.M005782200. PMID 10884395. 
  • Burtelow MA, Roos-Mattjus PM, Rauen M, et al. (2001). "Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex.". J. Biol. Chem. 276 (28): 25903-9. doi:10.1074/jbc.M102946200. PMID 11340080. 
  • Bao S, Tibbetts RS, Brumbaugh KM, et al. (2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.". Nature 411 (6840): 969-74. doi:10.1038/35082110. PMID 11418864. 
  • Xiang SL, Kumano T, Iwasaki SI, et al. (2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.". Biochem. Biophys. Res. Commun. 287 (4): 932-40. doi:10.1006/bbrc.2001.5685. PMID 11573955. 
  • Zou L, Cortez D, Elledge SJ (2002). "Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.". Genes Dev. 16 (2): 198-208. doi:10.1101/gad.950302. PMID 11799063. 
  • Griffith JD, Lindsey-Boltz LA, Sancar A (2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.". J. Biol. Chem. 277 (18): 15233-6. doi:10.1074/jbc.C200129200. PMID 11907025. 
  • Hang H, Zhang Y, Dunbrack RL, et al. (2002). "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1.". Genomics 79 (4): 487-92. doi:10.1006/geno.2002.6737. PMID 11944979. 
  • Hirai I, Wang HG (2002). "A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex.". J. Biol. Chem. 277 (28): 25722-7. doi:10.1074/jbc.M203079200. PMID 11994305. 
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