RAD17

From Wikipedia, the free encyclopedia

RAD17 homolog (S. pombe)

Identifiers

RAD17; CCYC; HRAD17; R24L; RAD17Sp; Rad24

External IDs

OMIM: 603139 MGI: 1333807 HomoloGene: 32117

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • nucleoside-triphosphatase activity
Cellular Component:	• nucleus
Biological Process:	• DNA replication checkpoint • DNA damage checkpoint • DNA repair • cell cycle • mitotic cell cycle checkpoint

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002873 (mRNA)
NP_002864 (protein)

NM_001044371 (mRNA)
NP_001037836 (protein)

Location

Chr 5: 68.7 - 68.75 Mb

Chr 13: 101.72 - 101.75 Mb

Pubmed search

[1]

[2]

RAD17 homolog (S. pombe), also known as RAD17, is a human gene.

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.^[1]

[edit] References

^ Entrez Gene: RAD17 RAD17 homolog (S. pombe).

[edit] Further reading

Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11-12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
al-Khodairy F, Carr AM (1992). "DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.". EMBO J. 11 (4): 1343–50. PMID 1563350.
Mossi R, Jónsson ZO, Allen BL, et al. (1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen.". J. Biol. Chem. 272 (3): 1769–76. PMID 8999859.
Parker AE, Van de Weyer I, Laus MC, et al. (1998). "Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene.". J. Biol. Chem. 273 (29): 18340–6. PMID 9660800.
Bao S, Shen X, Shen K, et al. (1999). "The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.". Cell Growth Differ. 9 (12): 961–7. PMID 9869296.
Dean FB, Lian L, O'Donnell M (1999). "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.". Genomics 54 (3): 424–36. doi:10.1006/geno.1998.5587. PMID 9878245.
Bluyssen HA, Naus NC, van Os RI, et al. (1999). "Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.". Genomics 55 (2): 219–28. doi:10.1006/geno.1998.5642. PMID 9933569.
Li L, Peterson CA, Kanter-Smoler G, et al. (1999). "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.". Oncogene 18 (9): 1689–99. doi:10.1038/sj.onc.1202469. PMID 10208430.
Bao S, Chang MS, Auclair D, et al. (1999). "HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.". Cancer Res. 59 (9): 2023–8. PMID 10232579.
von Deimling F, Scharf JM, Liehr T, et al. (1999). "Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma.". Hum. Genet. 105 (1-2): 17–27. PMID 10480350.
Chang MS, Sasaki H, Campbell MS, et al. (2000). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation.". J. Biol. Chem. 274 (51): 36544–9. PMID 10593953.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Burtelow MA, Kaufmann SH, Karnitz LM (2000). "Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage.". J. Biol. Chem. 275 (34): 26343–8. doi:10.1074/jbc.M001244200. PMID 10852904.
Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.". J. Biol. Chem. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Bao S, Tibbetts RS, Brumbaugh KM, et al. (2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.". Nature 411 (6840): 969–74. doi:10.1038/35082110. PMID 11418864.
Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). "Purification and characterization of human DNA damage checkpoint Rad complexes.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. doi:10.1073/pnas.201373498. PMID 11572977.
Chen MS, Higashikubo R, Laszlo A, Roti Roti J (2001). "Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation.". Gene 277 (1-2): 145–52. PMID 11602352.
Post S, Weng YC, Cimprich K, et al. (2001). "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 13102–7. doi:10.1073/pnas.231364598. PMID 11687627.