RABIF

From Wikipedia, the free encyclopedia

RAB interacting factor

PDB rendering based on 1fwq.

Available structures: 1fwq, 1hxr, 2fu5

Identifiers

Symbol(s)

RABIF; MSS4; RASGFR3; RASGRF3

External IDs

OMIM: 603417 MGI: 2138605 HomoloGene: 37702

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • zinc ion binding • metal ion binding
Biological Process:	• membrane fusion • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002871 (mRNA)
NP_002862 (protein)

NM_145510 (mRNA)
NP_663485 (protein)

Location

Chr 1: 201.11 - 201.12 Mb

Chr 1: 136.31 - 136.32 Mb

Pubmed search

[1]

[2]

RAB interacting factor, also known as RABIF, is a human gene.^[1]

The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RABIF RAB interacting factor.

[edit] Further reading

Yu H, Schreiber SL (1995). "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4.". Biochemistry 34 (28): 9103–10. PMID 7619808.
Yu H, Schreiber SL (1995). "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface.". Nature 376 (6543): 788–91. doi:10.1038/376788a0. PMID 7651540.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Burton JL, Slepnev V, De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4.". J. Biol. Chem. 272 (6): 3663–8. PMID 9013620.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Müller-Pillasch F, Zimmerhackl F, Lacher U, et al. (1998). "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer.". Genomics 46 (3): 389–96. doi:10.1006/geno.1997.5049. PMID 9441742.
Wixler V, Laplantine E, Geerts D, et al. (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.". FEBS Lett. 445 (2-3): 351–5. PMID 10094488.
Strick DJ, Francescutti DM, Zhao Y, Elferink LA (2002). "Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.". J. Biol. Chem. 277 (36): 32722–9. doi:10.1074/jbc.M205101200. PMID 12105226.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.