RAB9A

From Wikipedia, the free encyclopedia

RAB9A, member RAS oncogene family

PDB rendering based on 1s8f.

Available structures: 1s8f, 1wms, 1yzl

Identifiers

Symbol(s)

RAB9A; RAB9

External IDs

OMIM: 300284 MGI: 1890695 HomoloGene: 20900

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• lysosome • late endosome • membrane
Biological Process:	• small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004251 (mRNA)
NP_004242 (protein)

NM_019773 (mRNA)
NP_062747 (protein)

Location

Chr X: 13.62 - 13.64 Mb

Chr X: 161.8 - 161.82 Mb

Pubmed search

[1]

[2]

RAB9A, member RAS oncogene family, also known as RAB9A, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB9A RAB9A, member RAS oncogene family.

[edit] Further reading

Shapiro AD, Pfeffer SR (1995). "Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides.". J. Biol. Chem. 270 (19): 11085–90. PMID 7744738.
Soldati T, Riederer MA, Pfeffer SR (1993). "Rab GDI: a solubilizing and recycling factor for rab9 protein.". Mol. Biol. Cell 4 (4): 425–34. PMID 8389620.
Davies JP, Cotter PD, Ioannou YA (1997). "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene.". Genomics 41 (1): 131–4. doi:10.1006/geno.1997.4644. PMID 9126495.
Díaz E, Schimmöller F, Pfeffer SR (1997). "A novel Rab9 effector required for endosome-to-TGN transport.". J. Cell Biol. 138 (2): 283–90. PMID 9230071.
de Leeuw HP, Koster PM, Calafat J, et al. (1998). "Small GTP-binding proteins in human endothelial cells.". Br. J. Haematol. 103 (1): 15–9. PMID 9792283.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications.". Biochemistry 38 (36): 11711–21. PMID 10512627.
Carroll KS, Hanna J, Simon I, et al. (2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.". Science 292 (5520): 1373–6. doi:10.1126/science.1056791. PMID 11359012.
Orzaez D, de Jong AJ, Woltering EJ (2001). "A tomato homologue of the human protein PIRIN is induced during programmed cell death.". Plant Mol. Biol. 46 (4): 459–68. PMID 11485202.
Michel F, Soler-Lopez M, Petosa C, et al. (2002). "Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.". EMBO J. 20 (22): 6180–90. doi:10.1093/emboj/20.22.6180. PMID 11707390.
Barbero P, Bittova L, Pfeffer SR (2002). "Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells.". J. Cell Biol. 156 (3): 511–8. doi:10.1083/jcb.200109030. PMID 11827983.
Hanna J, Carroll K, Pfeffer SR (2002). "Identification of residues in TIP47 essential for Rab9 binding.". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7450–4. doi:10.1073/pnas.112198799. PMID 12032303.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Walter M, Davies JP, Ioannou YA (2004). "Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.". J. Lipid Res. 44 (2): 243–53. doi:10.1194/jlr.M200230-JLR200. PMID 12576506.
Seaman MN (2004). "Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.". J. Cell Biol. 165 (1): 111–22. doi:10.1083/jcb.200312034. PMID 15078902.
Chen L, DiGiammarino E, Zhou XE, et al. (2004). "High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target.". J. Biol. Chem. 279 (38): 40204–8. doi:10.1074/jbc.M407114200. PMID 15263003.
Ganley IG, Carroll K, Bittova L, Pfeffer S (2005). "Rab9 GTPase regulates late endosome size and requires effector interaction for its stability.". Mol. Biol. Cell 15 (12): 5420–30. doi:10.1091/mbc.E04-08-0747. PMID 15456905.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ganley IG, Pfeffer SR (2006). "Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.". J. Biol. Chem. 281 (26): 17890–9. doi:10.1074/jbc.M601679200. PMID 16644737.
Aivazian D, Serrano RL, Pfeffer S (2006). "TIP47 is a key effector for Rab9 localization.". J. Cell Biol. 173 (6): 917–26. doi:10.1083/jcb.200510010. PMID 16769818.