RAB6A

From Wikipedia, the free encyclopedia

RAB6A, member RAS oncogene family

PDB rendering based on 1yzq.

Available structures: 1yzq, 2fe4, 2ffq, 2gil

Identifiers

Symbol(s)

RAB6A; RAB6; RAB6A'; RAB6B

External IDs

OMIM: 179513 MGI: 894313 HomoloGene: 55697

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• Golgi apparatus
Biological Process:	• ER to Golgi vesicle-mediated transport • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002869 (mRNA)
NP_002860 (protein)

NM_024287 (mRNA)
NP_077249 (protein)

Location

Chr 11: 73.06 - 73.15 Mb

n/a

Pubmed search

[1]

[2]

RAB6A, member RAS oncogene family, also known as RAB6A, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB6A RAB6A, member RAS oncogene family.

[edit] Further reading

Rousseau-Merck MF, Zahraoui A, Touchot N, et al. (1991). "Chromosome assignment of four RAS-related RAB genes.". Hum. Genet. 86 (4): 350-4. PMID 1999336.
Goud B, Zahraoui A, Tavitian A, Saraste J (1990). "Small GTP-binding protein associated with Golgi cisternae.". Nature 345 (6275): 553-6. doi:10.1038/345553a0. PMID 2112230.
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394-401. PMID 2501306.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Beranger F, Cadwallader K, Porfiri E, et al. (1994). "Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase.". J. Biol. Chem. 269 (18): 13637-43. PMID 8175798.
Cremers FP, Armstrong SA, Seabra MC, et al. (1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene.". J. Biol. Chem. 269 (3): 2111-7. PMID 8294464.
Karniguian A, Zahraoui A, Tavitian A (1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7647-51. PMID 8356066.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Echard A, Jollivet F, Martinez O, et al. (1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6.". Science 279 (5350): 580-5. PMID 9438855.
Cuif MH, Possmayer F, Zander H, et al. (1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome.". EMBO J. 18 (7): 1772-82. doi:10.1093/emboj/18.7.1772. PMID 10202141.
Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins.". Curr. Biol. 9 (7): 381-4. PMID 10209123.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657-62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Caillol N, Pasqualini E, Lloubes R, Lombardo D (2000). "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells.". J. Cell. Biochem. 79 (4): 628-47. PMID 10996854.
Shan J, Mason JM, Yuan L, et al. (2001). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.". Gene 257 (1): 67-75. PMID 11054569.
Echard A, Opdam FJ, de Leeuw HJ, et al. (2001). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms.". Mol. Biol. Cell 11 (11): 3819-33. PMID 11071909.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.