RAB5B

From Wikipedia, the free encyclopedia

RAB5B, member RAS oncogene family

PDB rendering based on 1huq.

Available structures: 1huq, 1z07, 1z0d, 2hei

Identifiers

Symbol(s)

RAB5B;

External IDs

OMIM: 179514 HomoloGene: 88670

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding • GTP-dependent protein binding
Cellular Component:	• intracellular • membrane fraction • endosome • plasma membrane
Biological Process:	• small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_002868 (mRNA)
NP_002859 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 12: 54.65 - 54.67 Mb

n/a

Pubmed search

[1]

n/a

RAB5B, member RAS oncogene family, also known as RAB5B, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB5B RAB5B, member RAS oncogene family.

[edit] Further reading

Wilson DB, Wilson MP (1992). "Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases.". J. Clin. Invest. 89 (3): 996–1005. PMID 1541686.
Bucci C, Lütcke A, Steele-Mortimer O, et al. (1995). "Co-operative regulation of endocytosis by three Rab5 isoforms.". FEBS Lett. 366 (1): 65–71. PMID 7789520.
Korenberg JR, Chen XN, Adams MD, Venter JC (1996). "Toward a cDNA map of the human genome.". Genomics 29 (2): 364–70. PMID 8666383.
Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.". Horm. Metab. Res. 30 (11): 656–62. PMID 9918381.
Chiariello M, Bruni CB, Bucci C (1999). "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro.". FEBS Lett. 453 (1-2): 20–4. PMID 10403367.
Callaghan J, Nixon S, Bucci C, et al. (1999). "Direct interaction of EEA1 with Rab5b.". Eur. J. Biochem. 265 (1): 361–6. PMID 10491193.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.". Dev. Cell 1 (1): 73–82. PMID 11703925.
Saito K, Murai J, Kajiho H, et al. (2002). "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.". J. Biol. Chem. 277 (5): 3412–8. doi:10.1074/jbc.M106276200. PMID 11733506.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.". J. Cell. Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Hirota Y, Kuronita T, Fujita H, Tanaka Y (2007). "A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments.". Biochem. Biophys. Res. Commun. 364 (1): 40–7. doi:10.1016/j.bbrc.2007.09.089. PMID 17927960.