RAB5A

From Wikipedia, the free encyclopedia

RAB5A, member RAS oncogene family

PDB rendering based on 1huq.

Available structures: 1huq, 1n6h, 1n6i, 1n6k, 1n6l, 1n6n, 1n6o, 1n6p, 1n6r, 1r2q, 1tu3, 1tu4, 1z07, 1z0d

Identifiers

Symbol(s)

RAB5A; RAB5

External IDs

OMIM: 179512 MGI: 105926 HomoloGene: 68142

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• ruffle • early endosome • plasma membrane • endocytic vesicle • lipid raft
Biological Process:	• endocytosis • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004162 (mRNA)
NP_004153 (protein)

NM_025887 (mRNA)
NP_080163 (protein)

Location

Chr 3: 19.96 - 20 Mb

Chr 17: 52.94 - 52.97 Mb

Pubmed search

[1]

[2]

'RAB5A, member RAS oncogene family, also known as RAB5A, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB5A RAB5A, member RAS oncogene family.

[edit] Further reading

Bucci C, Parton RG, Mather IH, et al. (1992). "The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.". Cell 70 (5): 715-28. PMID 1516130.
Rousseau-Merck MF, Zahraoui A, Touchot N, et al. (1991). "Chromosome assignment of four RAS-related RAB genes.". Hum. Genet. 86 (4): 350-4. PMID 1999336.
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394-401. PMID 2501306.
Farnsworth CC, Seabra MC, Ericsson LH, et al. (1995). "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 11963-7. PMID 7991565.
Cremers FP, Armstrong SA, Seabra MC, et al. (1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene.". J. Biol. Chem. 269 (3): 2111-7. PMID 8294464.
Stenmark H, Vitale G, Ullrich O, Zerial M (1996). "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion.". Cell 83 (3): 423-32. PMID 8521472.
Vita F, Soranzo MR, Borelli V, et al. (1996). "Subcellular localization of the small GTPase Rab5a in resting and stimulated human neutrophils.". Exp. Cell Res. 227 (2): 367-73. doi:10.1006/excr.1996.0286. PMID 8831575.
Xiao GH, Shoarinejad F, Jin F, et al. (1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.". J. Biol. Chem. 272 (10): 6097-100. PMID 9045618.
Simonsen A, Lippé R, Christoforidis S, et al. (1998). "EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.". Nature 394 (6692): 494-8. doi:10.1038/28879. PMID 9697774.
Anant JS, Desnoyers L, Machius M, et al. (1999). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex.". Biochemistry 37 (36): 12559-68. doi:10.1021/bi980881a. PMID 9730828.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657-62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Callaghan J, Nixon S, Bucci C, et al. (1999). "Direct interaction of EEA1 with Rab5b.". Eur. J. Biochem. 265 (1): 361-6. PMID 10491193.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications.". Biochemistry 38 (36): 11711-21. PMID 10512627.
Masuda ES, Luo Y, Young C, et al. (2000). "Rab37 is a novel mast cell specific GTPase localized to secretory granules.". FEBS Lett. 470 (1): 61-4. PMID 10722846.
Hoffenberg S, Liu X, Nikolova L, et al. (2000). "A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.". J. Biol. Chem. 275 (32): 24661-9. doi:10.1074/jbc.M909600199. PMID 10818110.
Nielsen E, Christoforidis S, Uttenweiler-Joseph S, et al. (2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.". J. Cell Biol. 151 (3): 601-12. PMID 11062261.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Lanzetti L, Rybin V, Malabarba MG, et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.". Nature 408 (6810): 374-7. doi:10.1038/35042605. PMID 11099046.
Wolf RM, Wilkes JJ, Chao MV, Resh MD (2001). "Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.". J. Neurobiol. 49 (1): 62-78. PMID 11536198.
Seachrist JL, Laporte SA, Dale LB, et al. (2002). "Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion.". J. Biol. Chem. 277 (1): 679-85. doi:10.1074/jbc.M109022200. PMID 11682489.