RAB3D

From Wikipedia, the free encyclopedia

RAB3D, member RAS oncogene family

PDB rendering based on 2gf9.

Available structures: 2gf9

Identifiers

Symbol(s)

RAB3D; D2-2; GOV; RAB16; RAD3D

External IDs

OMIM: 604350 MGI: 97844 HomoloGene: 20902

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• membrane • zymogen granule
Biological Process:	• small GTPase mediated signal transduction • hemocyte development • protein transport • regulation of exocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004283 (mRNA)
NP_004274 (protein)

NM_031874 (mRNA)
NP_114080 (protein)

Location

Chr 19: 11.3 - 11.31 Mb

Chr 9: 21.66 - 21.67 Mb

Pubmed search

[1]

[2]

RAB3D, member RAS oncogene family, also known as RAB3D, is a human gene.^[1]

[edit] References

^ Entrez Gene: RAB3D RAB3D, member RAS oncogene family.

[edit] Further reading

Brondyk WH, McKiernan CJ, Fortner KA, et al. (1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A.". Mol. Cell. Biol. 15 (3): 1137–43. PMID 7532276.
Sehgal A, Keener C, Boynton AL, et al. (1997). "Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue.". Int. J. Cancer 71 (4): 565–72. PMID 9178809.
Raffaniello RD, Raufman JP (1999). "Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach.". J. Cell. Biochem. 72 (4): 540–8. PMID 10022613.
Nishio H, Suda T, Sawada K, et al. (1999). "Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation.". Biochim. Biophys. Acta 1444 (2): 283–90. PMID 10023084.
Chen XN, Shi ZY, Korenberg JR, Sehgal A (1999). "Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 83 (3-4): 230–1. PMID 10072586.
Cartel NJ, Wang J, Post M (2002). "Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.". Biochem. J. 363 (Pt 1): 19–28. PMID 11903042.
Riedel D, Antonin W, Fernandez-Chacon R, et al. (2002). "Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules.". Mol. Cell. Biol. 22 (18): 6487–97. PMID 12192047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Nguyen D, Jones A, Ojakian GK, et al. (2003). "Rab3D redistribution and function in rat parotid acini.". J. Cell. Physiol. 197 (3): 400–8. doi:10.1002/jcp.10373. PMID 14566969.
Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMID 15159548.
Knop M, Aareskjold E, Bode G, Gerke V (2005). "Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells.". EMBO J. 23 (15): 2982–92. doi:10.1038/sj.emboj.7600319. PMID 15257287.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.