RAB23

From Wikipedia, the free encyclopedia

RAB23, member RAS oncogene family

PDB rendering based on 1z22.

Available structures: 1z22, 1z2a

Identifiers

Symbol(s)

RAB23; DKFZp781H0695; HSPC137; MGC8900

External IDs

OMIM: 606144 MGI: 99833 HomoloGene: 7503

Gene ontology
Molecular Function:	• nucleotide binding • GTP binding
Cellular Component:	• membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction • nervous system development • dorsal/ventral pattern formation • protein transport • embryonic digit morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016277 (mRNA)
NP_057361 (protein)

NM_008999 (mRNA)
NP_033025 (protein)

Location

Chr 6: 57.16 - 57.2 Mb

Chr 1: 33.66 - 33.69 Mb

Pubmed search

[1]

[2]

RAB23, member RAS oncogene family, also known as RAB23, is a human gene.^[1]

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: RAB23 RAB23, member RAS oncogene family.

[edit] Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Marcos I, Borrego S, Antiñolo G (2004). "Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases.". Int. J. Mol. Med. 12 (6): 983–7. PMID 14612978.
Evans TM, Ferguson C, Wainwright BJ, et al. (2004). "Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.". Traffic 4 (12): 869–84. PMID 14617350.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Liu YJ, Wang Q, Li W, et al. (2007). "Rab23 is a potential biological target for treating hepatocellular carcinoma.". World J. Gastroenterol. 13 (7): 1010–7. PMID 17373734.
Jenkins D, Seelow D, Jehee FS, et al. (2007). "RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.". Am. J. Hum. Genet. 80 (6): 1162–70. doi:10.1086/518047. PMID 17503333.