RAB22A

From Wikipedia, the free encyclopedia

RAB22A, member RAS oncogene family

PDB rendering based on 1yvd.

Available structures: 1yvd, 1z0j

Identifiers

Symbol(s)

RAB22A; MGC16770

External IDs

MGI: 105072 HomoloGene: 10782

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• early endosome • plasma membrane
Biological Process:	• endocytosis • endosome organization and biogenesis • small GTPase mediated signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020673 (mRNA)
NP_065724 (protein)

NM_024436 (mRNA)
NP_077756 (protein)

Location

Chr 20: 56.32 - 56.38 Mb

Chr 2: 173.3 - 173.35 Mb

Pubmed search

[1]

[2]

RAB22A, member RAS oncogene family, also known as RAB22A, is a human gene.^[1]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.^[1]

[edit] References

^ ^a ^b Entrez Gene: RAB22A RAB22A, member RAS oncogene family.

[edit] Further reading

Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.". Horm. Metab. Res. 30 (11): 656–62. PMID 9918381.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Opdam FJ, Kamps G, Croes H, et al. (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells.". Eur. J. Cell Biol. 79 (5): 308–16. PMID 10887961.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Kauppi M, Simonsen A, Bremnes B, et al. (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking.". J. Cell. Sci. 115 (Pt 5): 899–911. PMID 11870209.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes.". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin.". Mol. Biol. Cell 15 (8): 3758–70. doi:10.1091/mbc.E04-04-0342. PMID 15181155.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mesa R, Magadán J, Barbieri A, et al. (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus.". Exp. Cell Res. 304 (2): 339–53. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Magadán JG, Barbieri MA, Mesa R, et al. (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes.". Mol. Cell. Biol. 26 (7): 2595–614. doi:10.1128/MCB.26.7.2595-2614.2006. PMID 16537905.