Pyruvate dehydrogenase (cytochrome)

From Wikipedia, the free encyclopedia

In enzymology, a pyruvate dehydrogenase (cytochrome) (EC 1.2.2.2) is an enzyme that catalyzes the chemical reaction

pyruvate + ferricytochrome b₁ + H₂O acetate + CO₂ + ferrocytochrome b₁

The 3 substrates of this enzyme are pyruvate, ferricytochrome b1, and H₂O, whereas its 3 products are acetate, CO₂, and ferrocytochrome b1.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is pyruvate:ferricytochrome-b1 oxidoreductase. Other names in common use include pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) dehydrogenase, pyruvate:ubiquinone-8-oxidoreductase, and pyruvate oxidase (ambiguous). This enzyme participates in pyruvate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.

[edit] References

• IUBMB entry for 1.2.2.2
• BRENDA references for 1.2.2.2 (Recommended.)
• PubMed references for 1.2.2.2
• PubMed Central references for 1.2.2.2
• Google Scholar references for 1.2.2.2
• Williams FR and Hager LP (1961). "A crystalline flavin pyruvate oxidase". J. Biol. Chem. 236: PC36–PC37. 
• Koland JG, Gennis RB (1982). "Identification of an active site cysteine residue in Escherichia coli pyruvate oxidase". J. Biol. Chem. 257: 6023–7. PMID 7042705. 

[edit] External links

The CAS registry number for this enzyme class is 9079-84-9.

• IUBMB entry for 1.2.2.2

• KEGG entry for 1.2.2.2

• BRENDA entry for 1.2.2.2

• NiceZyme view of 1.2.2.2

• EC2PDB: PDB structures for 1.2.2.2

• PRIAM entry for 1.2.2.2

• PUMA2 entry for 1.2.2.2

• IntEnz: Integrated Enzyme entry for 1.2.2.2

• MetaCyc entry for 1.2.2.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008985: pyruvate dehydrogenase (cytochrome)

• AMIGO entry for GO code 0008985: pyruvate dehydrogenase (cytochrome)