Pyrroloquinoline-quinone synthase

From Wikipedia, the free encyclopedia

In enzymology, a pyrroloquinoline-quinone synthase (EC 1.3.3.11) is an enzyme that catalyzes the chemical reaction

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ $\rightleftharpoons$ 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline- 2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O

The two substrates of this enzyme are 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate, and O₂, whereas its 3 products are 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate, H₂O₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinol ine-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing). This enzyme is also called PqqC.

[edit] References

IUBMB entry for 1.3.3.11
BRENDA references for 1.3.3.11 (Recommended.)
PubMed references for 1.3.3.11
PubMed Central references for 1.3.3.11
Google Scholar references for 1.3.3.11
Magnusson OT, Toyama H, Saeki M, Schwarzenbacher R, Klinman JP (2004). "The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis". J. Am. Chem. Soc. 126: 5342–3. doi:10.1021/ja0493852. PMID 15113189.
Klinman JP, Schwarzenbacher R (2004). "Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone". Proc. Natl. Acad. Sci. U. S. A. 101: 7913–8. doi:10.1073/pnas.0402640101. PMID 15148379.
Toyama H, Chistoserdova L, Lidstrom ME (Pt 2). "Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate". Microbiology. 143: 595–602. PMID 9043136.
Yasunaga K (1975). "[Concept of thrombocytopathy and problems involved in its diagnosis (author's transl)]". Nippon. Ketsueki. Gakkai. Zasshi. 38: 734–40. PMID 1243798.
RC (2004). "Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution". Proteins. 56: 401–3. doi:10.1002/prot.20085. PMID 15211525.