PURA

From Wikipedia, the free encyclopedia


Purine-rich element binding protein A
Identifiers
Symbol(s) PURA; PUR1; PUR-ALPHA; PURALPHA
External IDs OMIM: 600473 MGI: 103079 HomoloGene: 4279
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5813 19290
Ensembl ENSG00000185129 ENSMUSG00000043991
Uniprot Q00577 Q8C6E9
Refseq NM_005859 (mRNA)
NP_005850 (protein)		 XM_987644 (mRNA)
XP_992738 (protein)
Location Chr 5: 139.47 - 139.48 Mb Chr 18: 36.41 - 36.41 Mb
Pubmed search [1] [2]

Purine-rich element binding protein A, also known as PURA, is a human gene.

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.[1]

[edit] References

  1. ^ Entrez Gene: PURA purine-rich element binding protein A.

[edit] Further reading

  • Gallia GL, Johnson EM, Khalili K (2000). "Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein.". Nucleic Acids Res. 28 (17): 3197–205. PMID 10954586. 
  • Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway.". J. Neurovirol. 8 Suppl 2: 91–6. doi:10.1080/13550280290167885. PMID 12491158. 
  • Bergemann AD, Ma ZW, Johnson EM (1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein.". Mol. Cell. Biol. 12 (12): 5673–82. PMID 1448097. 
  • Bergemann AD, Johnson EM (1992). "The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication.". Mol. Cell. Biol. 12 (3): 1257–65. PMID 1545807. 
  • Johnson EM, Chen PL, Krachmarov CP, et al. (1995). "Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element.". J. Biol. Chem. 270 (41): 24352–60. PMID 7592647. 
  • Ma ZW, Pejovic T, Najfeld V, et al. (1995). "Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Pur alpha, to chromosome band 5q31.". Cytogenet. Cell Genet. 71 (1): 64–7. PMID 7606931. 
  • Chen NN, Chang CF, Gallia GL, et al. (1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element.". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. PMID 7862639. 
  • Jurk M, Weissinger F, Lottspeich F, et al. (1996). "Characterization of the single-strand-specific BPV-1 origin binding protein, SPSF I, as the HeLa Pur alpha factor.". Nucleic Acids Res. 24 (14): 2799–806. PMID 8759014. 
  • Krachmarov CP, Chepenik LG, Barr-Vagell S, et al. (1997). "Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14112–7. PMID 8943069. 
  • Kelm RJ, Elder PK, Strauch AR, Getz MJ (1997). "Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Puralpha and Purbeta.". J. Biol. Chem. 272 (42): 26727–33. PMID 9334258. 
  • Thatikunta P, Sawaya BE, Denisova L, et al. (1998). "Identification of a cellular protein that binds to Tat-responsive element of TGF beta-1 promoter in glial cells.". J. Cell. Biochem. 67 (4): 466–77. PMID 9383706. 
  • Itoh H, Wortman MJ, Kanovsky M, et al. (1998). "Alterations in Pur(alpha) levels and intracellular localization in the CV-1 cell cycle.". Cell Growth Differ. 9 (8): 651–65. PMID 9716182. 
  • Gallia GL, Safak M, Khalili K (1999). "Interaction of the single-stranded DNA-binding protein Puralpha with the human polyomavirus JC virus early protein T-antigen.". J. Biol. Chem. 273 (49): 32662–9. PMID 9830007. 
  • Safak M, Gallia GL, Khalili K (1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells.". Mol. Cell. Biol. 19 (4): 2712–23. PMID 10082537. 
  • Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter.". J. Biol. Chem. 274 (20): 14238–45. PMID 10318844. 
  • Gallia GL, Darbinian N, Johnson EM, Khalili K (1999). "Self-association of Puralpha is mediated by RNA.". J. Cell. Biochem. 74 (3): 334–48. PMID 10412036. 
  • Tretiakova A, Steplewski A, Johnson EM, et al. (1999). "Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association of Sp1 and Puralpha in brain.". J. Cell. Physiol. 181 (1): 160–8. doi:10.1002/(SICI)1097-4652(199910)181:1<160::AID-JCP17>3.0.CO;2-H. PMID 10457364. 
  • Gallia GL, Darbinian N, Tretiakova A, et al. (1999). "Association of HIV-1 Tat with the cellular protein, Puralpha, is mediated by RNA.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11572–7. PMID 10500218. 
  • Darbinian N, Gallia GL, Kundu M, et al. (2000). "Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1.". Oncogene 18 (46): 6398–402. doi:10.1038/sj.onc.1203011. PMID 10597240. 
  • Wortman MJ, Krachmarov CP, Kim JH, et al. (2000). "Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding.". J. Cell. Biochem. 77 (1): 65–74. PMID 10679817. 
 This article on a gene on chromosome 5 is a stub. You can help Wikipedia by expanding it.