PTX3

From Wikipedia, the free encyclopedia

Pentraxin-related gene, rapidly induced by IL-1 beta

Identifiers

PTX3; TNFAIP5; TSG-14

External IDs

OMIM: 602492 MGI: 104641 HomoloGene: 7500

Gene ontology
Molecular Function:	• zymosan binding
Cellular Component:	• extracellular region
Biological Process:	• response to yeast • inflammatory response • opsonization • positive regulation of nitric oxide biosynthetic process • positive regulation of phagocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002852 (mRNA)
NP_002843 (protein)

NM_008987 (mRNA)
NP_033013 (protein)

Location

Chr 3: 158.64 - 158.64 Mb

Chr 3: 66.31 - 66.31 Mb

Pubmed search

[1]

[2]

Pentraxin-related gene, rapidly induced by IL-1 beta, also known as PTX3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PTX3 Pentraxin-related gene, rapidly induced by IL-1 beta.

[edit] Further reading

Mantovani A, Garlanda C, Bottazzi B (2004). "Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity.". Vaccine 21 Suppl 2: S43-7. PMID 12763682.
He X, Han B, Liu M (2007). "Long pentraxin 3 in pulmonary infection and acute lung injury.". Am. J. Physiol. Lung Cell Mol. Physiol. 292 (5): L1039-49. doi:10.1152/ajplung.00490.2006. PMID 17277044.
Breviario F, d'Aniello EM, Golay J, et al. (1992). "Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.". J. Biol. Chem. 267 (31): 22190-7. PMID 1429570.
Lee TH, Wisniewski HG, Vilcek J (1992). "A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.". J. Cell Biol. 116 (2): 545-57. PMID 1730767.
Lee GW, Goodman AR, Lee TH, Vilcek J (1994). "Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins.". J. Immunol. 153 (8): 3700-7. PMID 7523502.
Lee GW, Lee TH, Vilcek J (1993). "TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins.". J. Immunol. 150 (5): 1804-12. PMID 7679696.
Alles VV, Bottazzi B, Peri G, et al. (1994). "Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes.". Blood 84 (10): 3483-93. PMID 7949102.
Introna M, Breviario F, d'Aniello EM, et al. (1994). "IL-1 inducible genes in human umbilical vein endothelial cells.". Eur. Heart J. 14 Suppl K: 78-81. PMID 8131794.
Vouret-Craviari V, Matteucci C, Peri G, et al. (1997). "Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan.". Infect. Immun. 65 (4): 1345-50. PMID 9119472.
Bottazzi B, Vouret-Craviari V, Bastone A, et al. (1998). "Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component.". J. Biol. Chem. 272 (52): 32817-23. PMID 9407058.
Polentarutti N, Picardi G, Basile A, et al. (1998). "Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes.". Eur. J. Immunol. 28 (2): 496-501. PMID 9521058.
Peri G, Introna M, Corradi D, et al. (2000). "PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans.". Circulation 102 (6): 636-41. PMID 10931803.
Fazzini F, Peri G, Doni A, et al. (2002). "PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation.". Arthritis Rheum. 44 (12): 2841-50. PMID 11762945.
Klouche M, Brockmeyer N, Knabbe C, Rose-John S (2002). "Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells.". AIDS 16 (8): F9-18. PMID 12004288.
Napoleone E, Di Santo A, Bastone A, et al. (2002). "Long pentraxin PTX3 upregulates tissue factor expression in human endothelial cells: a novel link between vascular inflammation and clotting activation.". Arterioscler. Thromb. Vasc. Biol. 22 (5): 782-7. PMID 12006390.
Rolph MS, Zimmer S, Bottazzi B, et al. (2002). "Production of the long pentraxin PTX3 in advanced atherosclerotic plaques.". Arterioscler. Thromb. Vasc. Biol. 22 (5): e10-4. PMID 12006411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bussolati B, Peri G, Salvidio G, et al. (2003). "The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells.". J. Immunol. 170 (3): 1466-72. PMID 12538709.
Abderrahim-Ferkoune A, Bezy O, Chiellini C, et al. (2004). "Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells.". J. Lipid Res. 44 (5): 994-1000. doi:10.1194/jlr.M200382-JLR200. PMID 12611905.
Nauta AJ, Bottazzi B, Mantovani A, et al. (2003). "Biochemical and functional characterization of the interaction between pentraxin 3 and C1q.". Eur. J. Immunol. 33 (2): 465-73. doi:10.1002/immu.200310022. PMID 12645945.