PTRF

From Wikipedia, the free encyclopedia

Polymerase I and transcript release factor

Identifiers

PTRF; FKSG13

External IDs

OMIM: 603198 MGI: 1277968 HomoloGene: 7499

Gene ontology
Molecular Function:	• RNA polymerase I transcription termination factor activity • protein binding • rRNA primary transcript binding
Cellular Component:	• nucleus • membrane
Biological Process:	• transcription • transcription termination • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase I promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012232 (mRNA)
NP_036364 (protein)

NM_008986 (mRNA)
NP_033012 (protein)

Location

Chr 17: 37.81 - 37.83 Mb

Chr 11: 100.77 - 100.79 Mb

Pubmed search

[1]

[2]

Polymerase I and transcript release factor, also known as PTRF, is a human gene.^[1]

[edit] References

^ Entrez Gene: PTRF polymerase I and transcript release factor.

[edit] Further reading

Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMID 9582279.
Hasegawa T, Takeuchi A, Miyaishi O, et al. (2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.". Biochem. J. 347 Pt 1: 55–9. PMID 10727401.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMID 15242332.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Aboulaich N, Ortegren U, Vener AV, Strålfors P (2006). "Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.". Biochem. Biophys. Res. Commun. 350 (3): 657–61. doi:10.1016/j.bbrc.2006.09.094. PMID 17026959.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.