PTPRG

From Wikipedia, the free encyclopedia

Protein tyrosine phosphatase, receptor type, G

PDB rendering based on 2h4v.

Available structures: 2h4v, 2hy3, 2nlk, 2pbn

Identifiers

Symbol(s)

PTPRG; HPTPG; PTPG; R-PTP-GAMMA; RPTPG

External IDs

OMIM: 176886 MGI: 97814 HomoloGene: 2129

Gene ontology
Molecular Function:	• carbonate dehydratase activity • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • zinc ion binding • hydrolase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid dephosphorylation • one-carbon compound metabolic process • transmembrane receptor protein tyrosine kinase signaling pathway

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002841 (mRNA)
NP_002832 (protein)

XM_976892 (mRNA)
XP_981986 (protein)

Location

Chr 3: 61.52 - 62.26 Mb

n/a

Pubmed search

[1]

[2]

Protein tyrosine phosphatase, receptor type, G, also known as PTPRG, is a human gene.^[1]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G.

[edit] Further reading

LaForgia S, Morse B, Levy J, et al. (1991). "Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 5036–40. PMID 1711217.
Kaplan R, Morse B, Huebner K, et al. (1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7000–4. PMID 2169617.
Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.". EMBO J. 9 (10): 3241–52. PMID 2170109.
Latif F, Tory K, Modi W, et al. (1993). "A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene.". Hum. Mol. Genet. 2 (1): 91. PMID 7683956.
Barnea G, Silvennoinen O, Shaanan B, et al. (1993). "Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases.". Mol. Cell. Biol. 13 (3): 1497–506. PMID 8382771.
Kastury K, Ohta M, Lasota J, et al. (1997). "Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation.". Genomics 32 (2): 225–35. doi:10.1006/geno.1996.0109. PMID 8833149.
van Niekerk CC, Poels LG (1999). "Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors.". Cancer Lett. 137 (1): 61–73. PMID 10376795.
Kawachi H, Tamura H, Watakabe I, et al. (1999). "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family.". Brain Res. Mol. Brain Res. 72 (1): 47–54. PMID 10521598.
Liu S, Kulp SK, Sugimoto Y, et al. (2002). "Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents.". Breast Cancer Res. Treat. 71 (1): 21–35. PMID 11859871.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu S, Sugimoto Y, Kulp SK, et al. (2003). "Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha.". Anticancer Res. 22 (6C): 3917–23. PMID 12553013.
Liu S, Sugimoto Y, Sorio C, et al. (2004). "Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7.". Oncogene 23 (6): 1256–62. doi:10.1038/sj.onc.1207235. PMID 14676845.
van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.". J. Clin. Oncol. 23 (17): 3886–96. doi:10.1200/JCO.2005.11.353. PMID 15897551.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.