PTK6

From Wikipedia, the free encyclopedia

PTK6 protein tyrosine kinase 6

PDB rendering based on 1rja.

Available structures: 1rja

Identifiers

Symbol(s)

PTK6; BRK; FLJ42088

External IDs

OMIM: 602004 MGI: 99683 HomoloGene: 68494

Gene ontology
Molecular Function:	• nucleotide binding • non-membrane spanning protein tyrosine kinase activity • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005975 (mRNA)
NP_005966 (protein)

NM_009184 (mRNA)
NP_033210 (protein)

Location

Chr 20: 61.63 - 61.64 Mb

Chr 2: 181.12 - 181.13 Mb

Pubmed search

[1]

[2]

PTK6 protein tyrosine kinase 6, also known as PTK6, is a human gene.^[1]

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.^[1]

[edit] References

^ ^a ^b Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6.

[edit] Further reading

Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.". Oncol. Res. 13 (6-10): 409–19. PMID 12725532.
Mitchell PJ, Barker KT, Martindale JE, et al. (1994). "Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.". Oncogene 9 (8): 2383–90. PMID 8036022.
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403–10. PMID 8247543.
Kamalati T, Jolin HE, Mitchell PJ, et al. (1997). "Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor.". J. Biol. Chem. 271 (48): 30956–63. PMID 8940083.
Park SH, Lee KH, Kim H, Lee ST (1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 77 (3-4): 271–2. PMID 9284935.
Lee H, Kim M, Lee KH, et al. (1998). "Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase.". Mol. Cells 8 (4): 401–7. PMID 9749526.
Llor X, Serfas MS, Bie W, et al. (1999). "BRK/Sik expression in the gastrointestinal tract and in colon tumors.". Clin. Cancer Res. 5 (7): 1767–77. PMID 10430081.
Derry JJ, Richard S, Valderrama Carvajal H, et al. (2000). "Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.". Mol. Cell. Biol. 20 (16): 6114–26. PMID 10913193.
Mitchell PJ, Sara EA, Crompton MR (2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK.". Oncogene 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID 10980601.
Kamalati T, Jolin HE, Fry MJ, Crompton MR (2000). "Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation.". Oncogene 19 (48): 5471–6. doi:10.1038/sj.onc.1203931. PMID 11114724.
Hong E, Shin J, Bang E, et al. (2001). "Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain.". J. Biomol. NMR 19 (3): 291–2. PMID 11330822.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Kang KN, Kim M, Pae KM, Lee ST (2002). "Characterization of the 5'-flanking region of the human PTK6 gene.". Biochim. Biophys. Acta 1574 (3): 365–9. PMID 11997104.
Qiu H, Miller WT (2002). "Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition.". J. Biol. Chem. 277 (37): 34634–41. doi:10.1074/jbc.M203877200. PMID 12121988.
Koo BK, Kim MH, Lee ST, Lee W (2002). "Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain.". J. Biochem. Mol. Biol. 35 (3): 343–7. PMID 12297019.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Coyle JH, Guzik BW, Bor YC, et al. (2003). "Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.". Mol. Cell. Biol. 23 (1): 92–103. PMID 12482964.
Derry JJ, Prins GS, Ray V, Tyner AL (2003). "Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells.". Oncogene 22 (27): 4212–20. doi:10.1038/sj.onc.1206465. PMID 12833144.
Qiu H, Miller WT (2004). "Role of the Brk SH3 domain in substrate recognition.". Oncogene 23 (12): 2216–23. doi:10.1038/sj.onc.1207339. PMID 14676834.