PTK2

From Wikipedia, the free encyclopedia

PTK2 protein tyrosine kinase 2

PDB rendering based on 1k04.

Available structures: 1k04, 1k05, 1k40, 1ktm, 1mp8, 1ow6, 1ow7, 1ow8, 1pv3, 1qvx, 2aeh, 2al6, 2etm

Identifiers

Symbol(s)

PTK2; FADK; FAK; FAK1; pp125FAK

External IDs

OMIM: 600758 MGI: 95481 HomoloGene: 7314

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity • SH2 domain binding
Cellular Component:	• cytoskeleton • focal adhesion • apical plasma membrane • lamellipodium
Biological Process:	• microtubule cytoskeleton organization and biogenesis • blood vessel development • neuron migration • protein amino acid phosphorylation • integrin-mediated signaling pathway • extracellular matrix organization and biogenesis • establishment of nucleus localization • negative regulation of organ size

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005607 (mRNA)
NP_005598 (protein)

NM_007982 (mRNA)
NP_032008 (protein)

Location

Chr 8: 141.74 - 142.08 Mb

Chr 15: 73.03 - 73.25 Mb

Pubmed search

[1]

[2]

PTK2 protein tyrosine kinase 2, also known as PTK2, is a human gene.

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.^[1]

[edit] See also

Tyrosine kinase

[edit] References

^ Entrez Gene: PTK2 PTK2 protein tyrosine kinase 2.

[edit] Further reading

Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes.". J. Dermatol. Sci. 23 (2): 75–86. PMID 10808124.
Schaller MD (2001). "Biochemical signals and biological responses elicited by the focal adhesion kinase.". Biochim. Biophys. Acta 1540 (1): 1–21. PMID 11476890.
Panetti TS (2002). "Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration.". Front. Biosci. 7: d143–50. PMID 11779709.
Hauck CR, Hsia DA, Schlaepfer DD (2003). "The focal adhesion kinase--a regulator of cell migration and invasion.". IUBMB Life 53 (2): 115–9. PMID 12049193.
Hanks SK, Ryzhova L, Shin NY, Brábek J (2004). "Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility.". Front. Biosci. 8: d982–96. PMID 12700132.
Gabarra-Niecko V, Schaller MD, Dunty JM (2004). "FAK regulates biological processes important for the pathogenesis of cancer.". Cancer Metastasis Rev. 22 (4): 359–74. PMID 12884911.