PSRC1

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Proline/serine-rich coiled-coil 1
Identifiers
Symbol(s) PSRC1; DDA3; FP3214; MGC1780; RP11-297O4.2
External IDs MGI: 1913099 HomoloGene: 49603
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 84722 56742
Ensembl ENSG00000134222 ENSMUSG00000068744
Uniprot Q6PGN9 Q8BT86
Refseq NM_001005290 (mRNA)
NP_001005290 (protein)		 NM_019976 (mRNA)
NP_064360 (protein)
Location Chr 1: 109.62 - 109.63 Mb Chr 3: 108.51 - 108.52 Mb
Pubmed search [1] [2]

Proline/serine-rich coiled-coil 1, also known as PSRC1, is a human gene.[1]

This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1.

[edit] Further reading

  • Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.". Nat. Genet. 40 (2): 189-97. doi:10.1038/ng.75. PMID 18193044. 
  • Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.". Am. J. Hum. Genet. 82 (1): 139-49. doi:10.1016/j.ajhg.2007.11.001. PMID 18179892. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:10.1073/pnas.0404089101. PMID 15498874. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lo PK, Wang FF (2003). "Cloning and characterization of human and mouse DDA3 genes.". Biochim. Biophys. Acta 1579 (2-3): 214-8. PMID 12427559. 
  • Lo PK, Chen JY, Lo WC, et al. (2000). "Identification of a novel mouse p53 target gene DDA3.". Oncogene 18 (54): 7765-74. doi:10.1038/sj.onc.1203167. PMID 10618717. 
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