PSMF1

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Identifiers

External IDs

Gene ontology
Molecular Function:	• protein binding • proteasome inhibitor activity
Cellular Component:	• cytosol • proteasome core complex (sensu Eukaryota)
Biological Process:	• ubiquitin-dependent protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006814 (mRNA)
NP_006805 (protein)

NM_144889 (mRNA)
NP_659138 (protein)

Location

Chr 20: 1.04 - 1.1 Mb

Chr 2: 151.41 - 151.43 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) inhibitor subunit 1 (PI31), also known as PSMF1, is a human gene.^[1]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31).

[edit] Further reading

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Peruzzi F (2006). "The multiple functions of HIV-1 Tat: proliferation versus apoptosis.". Front. Biosci. 11: 708–17. PMID 16146763.
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Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770.
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Zaiss DM, Standera S, Kloetzel PM, Sijts AJ (2002). "PI31 is a modulator of proteasome formation and antigen processing.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14344–9. doi:10.1073/pnas.212257299. PMID 12374861.
Huang X, Seifert U, Salzmann U, et al. (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.". J. Mol. Biol. 323 (4): 771–82. PMID 12419264.