PSMD4

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

PDB rendering based on 1p9c.

Available structures: 1p9c, 1p9d, 1uel, 1yx4, 1yx5, 1yx6

Identifiers

Symbol(s)

PSMD4; ASF; AF-1; AF; MCB1; Rpn10; S5A; pUB-R5

External IDs

OMIM: 601648 MGI: 1201670 HomoloGene: 55691

Gene ontology
Cellular Component:	• proteasome complex (sensu Eukaryota) • cytosol

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002810 (mRNA)
NP_002801 (protein)

NM_008951 (mRNA)
NP_032977 (protein)

Location

Chr 1: 149.49 - 149.51 Mb

Chr 3: 95.12 - 95.12 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, also known as PSMD4, is a human gene.^[1]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4.

[edit] Further reading

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801-47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281-3. PMID 12914693.
Lönnroth I, Lange S (1986). "Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin.". Biochim. Biophys. Acta 883 (1): 138-44. PMID 3524692.
Johansson E, Lönnroth I, Lange S, et al. (1995). "Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion.". J. Biol. Chem. 270 (35): 20615-20. PMID 7657640.
Ferrell K, Deveraux Q, van Nocker S, Rechsteiner M (1996). "Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease.". FEBS Lett. 381 (1-2): 143-8. PMID 8641424.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145-8. PMID 9079628.
Anand G, Yin X, Shahidi AK, et al. (1997). "Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome.". J. Biol. Chem. 272 (31): 19140-51. PMID 9235903.
Young P, Deveraux Q, Beal RE, et al. (1998). "Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.". J. Biol. Chem. 273 (10): 5461-7. PMID 9488668.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251-5. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397-400. doi:10.1038/3987. PMID 9846577.
Hiyama H, Yokoi M, Masutani C, et al. (1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.". J. Biol. Chem. 274 (39): 28019-25. PMID 10488153.
Tateishi K, Misumi Y, Ikehara Y, et al. (1999). "Molecular cloning and expression of rat antisecretory factor and its intracellular localization.". Biochem. Cell Biol. 77 (3): 223-8. PMID 10505793.
Tanahashi N, Murakami Y, Minami Y, et al. (2000). "Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.". J. Biol. Chem. 275 (19): 14336-45. PMID 10799514.
Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749-53. doi:10.1074/jbc.M004670200. PMID 10893419.
Kawahara H, Kasahara M, Nishiyama A, et al. (2000). "Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes.". EMBO J. 19 (15): 4144-53. doi:10.1093/emboj/19.15.4144. PMID 10921894.
Connell P, Ballinger CA, Jiang J, et al. (2001). "The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins.". Nat. Cell Biol. 3 (1): 93-6. doi:10.1038/35050618. PMID 11146632.
Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET (2002). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1.". J. Biol. Chem. 276 (49): 46655-60. doi:10.1074/jbc.M108636200. PMID 11585840.
Walters KJ, Kleijnen MF, Goh AM, et al. (2002). "Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.". Biochemistry 41 (6): 1767-77. PMID 11827521.
Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.". Nature 418 (6898): 646-50. doi:10.1038/nature00939. PMID 12167863.