PSMC5

From Wikipedia, the free encyclopedia


Proteasome (prosome, macropain) 26S subunit, ATPase, 5
Identifiers
Symbol(s) PSMC5; p45; S8; SUG1; TBP10; TRIP1; p45/SUG
External IDs OMIM: 601681 MGI: 105047 HomoloGene: 2098
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5705 19184
Ensembl ENSG00000087191 ENSMUSG00000020708
Uniprot P62195 Q99KR1
Refseq NM_002805 (mRNA)
NP_002796 (protein)		 NM_008950 (mRNA)
NP_032976 (protein)
Location Chr 17: 59.26 - 59.26 Mb Chr 11: 106.07 - 106.08 Mb
Pubmed search [1] [2]

Proteasome (prosome, macropain) 26S subunit, ATPase, 5, also known as PSMC5, is a human gene.[1]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.[1]

[edit] References

  1. ^ a b Entrez Gene: PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5.

[edit] Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196. 
  • Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693. 
  • Nelbock P, Dillon PJ, Perkins A, Rosen CA (1990). "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator.". Science 248 (4963): 1650–3. PMID 2194290. 
  • Akiyama K, Yokota K, Kagawa S, et al. (1995). "cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p.". FEBS Lett. 363 (1-2): 151–6. PMID 7729537. 
  • Lee JW, Choi HS, Gyuris J, et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.". Mol. Endocrinol. 9 (2): 243–54. PMID 7776974. 
  • Lee JW, Ryan F, Swaffield JC, et al. (1995). "Interaction of thyroid-hormone receptor with a conserved transcriptional mediator.". Nature 374 (6517): 91–4. doi:10.1038/374091a0. PMID 7870181. 
  • Shaw DR, Ennis HL (1993). "Molecular cloning and developmental regulation of Dictyostelium discoideum homologues of the human and yeast HIV1 Tat-binding protein.". Biochem. Biophys. Res. Commun. 193 (3): 1291–6. doi:10.1006/bbrc.1993.1765. PMID 8323548. 
  • Ohana B, Moore PA, Ruben SM, et al. (1993). "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 138–42. PMID 8419915. 
  • Dubiel W, Ferrell K, Rechsteiner M (1993). "Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease.". FEBS Lett. 323 (3): 276–8. PMID 8500623. 
  • vom Baur E, Zechel C, Heery D, et al. (1996). "Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.". EMBO J. 15 (1): 110–24. PMID 8598193. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Wang W, Chevray PM, Nathans D (1996). "Mammalian Sug1 and c-Fos in the nuclear 26S proteasome.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8236–40. PMID 8710853. 
  • Hoyle J, Tan KH, Fisher EM (1997). "Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1).". Hum. Genet. 99 (2): 285–8. PMID 9048938. 
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Weeda G, Rossignol M, Fraser RA, et al. (1997). "The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.". Nucleic Acids Res. 25 (12): 2274–83. PMID 9173976. 
  • Chen Y, Sharp ZD, Lee WH (1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins.". J. Biol. Chem. 272 (38): 24081–7. PMID 9295362. 
  • Tipler CP, Hutchon SP, Hendil K, et al. (1998). "Purification and characterization of 26S proteasomes from human and mouse spermatozoa.". Mol. Hum. Reprod. 3 (12): 1053–60. PMID 9464850. 
  • Tanahashi N, Suzuki M, Fujiwara T, et al. (1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases.". Biochem. Biophys. Res. Commun. 243 (1): 229–32. PMID 9473509. 
 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.