PSMC3

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) 26S subunit, ATPase, 3

Identifiers

PSMC3; MGC8487; TBP1

External IDs

OMIM: 186852 MGI: 1098754 HomoloGene: 2097

Gene ontology
Molecular Function:	• nucleotide binding • transcription coactivator activity • transcription corepressor activity • ATP binding • hydrolase activity • nucleoside-triphosphatase activity
Cellular Component:	• proteasome complex (sensu Eukaryota) • nucleus • cytoplasm • cytosol
Biological Process:	• protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002804 (mRNA)
NP_002795 (protein)

NM_008948 (mRNA)
NP_032974 (protein)

Location

Chr 11: 47.4 - 47.4 Mb

Chr 2: 90.85 - 90.87 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) 26S subunit, ATPase, 3, also known as PSMC3, is a human gene.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.^[1]

[edit] References

^ Entrez Gene: PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3.

[edit] Further reading

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693.
Nelbock P, Dillon PJ, Perkins A, Rosen CA (1990). "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator.". Science 248 (4963): 1650–3. PMID 2194290.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Shaw DR, Ennis HL (1993). "Molecular cloning and developmental regulation of Dictyostelium discoideum homologues of the human and yeast HIV1 Tat-binding protein.". Biochem. Biophys. Res. Commun. 193 (3): 1291–6. doi:10.1006/bbrc.1993.1765. PMID 8323548.
Ohana B, Moore PA, Ruben SM, et al. (1993). "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 138–42. PMID 8419915.
Dubiel W, Ferrell K, Rechsteiner M (1993). "Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease.". FEBS Lett. 323 (3): 276–8. PMID 8500623.
DeMartino GN, Proske RJ, Moomaw CR, et al. (1996). "Identification, purification, and characterization of a PA700-dependent activator of the proteasome.". J. Biol. Chem. 271 (6): 3112–8. PMID 8621709.
Hoyle J, Tan KH, Fisher EM (1997). "Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1).". Hum. Genet. 99 (2): 285–8. PMID 9048938.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.
Tanaka T, Nakamura T, Takagi H, Sato M (1997). "Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP.". Biochem. Biophys. Res. Commun. 239 (1): 176–81. doi:10.1006/bbrc.1997.7447. PMID 9345291.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Tanahashi N, Suzuki M, Fujiwara T, et al. (1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases.". Biochem. Biophys. Res. Commun. 243 (1): 229–32. PMID 9473509.
Nakamura T, Tanaka T, Takagi H, Sato M (1998). "Cloning and heterogeneous in vivo expression of Tat binding protein-1 (TBP-1) in the mouse.". Biochim. Biophys. Acta 1399 (1): 93–100. PMID 9714759.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
Park BW, O'Rourke DM, Wang Q, et al. (1999). "Induction of the Tat-binding protein 1 gene accompanies the disabling of oncogenic erbB receptor tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6434–8. PMID 10339605.
Tanahashi N, Murakami Y, Minami Y, et al. (2000). "Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.". J. Biol. Chem. 275 (19): 14336–45. PMID 10799514.
Ijichi H, Tanaka T, Nakamura T, et al. (2000). "Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene.". Gene 248 (1-2): 99–107. PMID 10806355.