PSMB9

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)

Identifiers

PSMB9; LMP2; MGC70470; RING12

External IDs

OMIM: 177045 MGI: 1346526 HomoloGene: 2094

Gene ontology
Molecular Function:	• threonine endopeptidase activity
Cellular Component:	• cytosol • proteasome core complex (sensu Eukaryota)
Biological Process:	• proteolysis • ubiquitin-dependent protein catabolic process • immune response • antigen processing and presentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002800 (mRNA)
NP_002791 (protein)

NM_013585 (mRNA)
NP_038613 (protein)

Location

Chr 6: 32.93 - 32.94 Mb

Chr 17: 33.79 - 33.8 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2), also known as PSMB9, is a human gene.^[1]

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified; both isoforms are processed to yield the same mature subunit.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2).

[edit] Further reading

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693.
Früh K, Yang Y, Arnold D, et al. (1992). "Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.". J. Biol. Chem. 267 (31): 22131–40. PMID 1429565.
Beck S, Kelly A, Radley E, et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.". J. Mol. Biol. 228 (2): 433–41. PMID 1453454.
Bodmer JG, Marsh SG, Albert ED, et al. (1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system.". Tissue Antigens 39 (4): 161–73. PMID 1529427.
Martinez CK, Monaco JJ (1991). "Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene.". Nature 353 (6345): 664–7. doi:10.1038/353664a0. PMID 1681432.
Kelly A, Powis SH, Glynne R, et al. (1991). "Second proteasome-related gene in the human MHC class II region.". Nature 353 (6345): 667–8. doi:10.1038/353667a0. PMID 1922385.
Kristensen P, Johnsen AH, Uerkvitz W, et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing.". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.
Singal DP, Ye M, Quadri SA (1995). "Major histocompatibility-encoded human proteasome LMP2. Genomic organization and a new form of mRNA.". J. Biol. Chem. 270 (4): 1966–70. PMID 7829535.
Beck S, Abdulla S, Alderton RP, et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
Hisamatsu H, Shimbara N, Saito Y, et al. (1996). "Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.". J. Exp. Med. 183 (4): 1807–16. PMID 8666937.
Schmidtke G, Kraft R, Kostka S, et al. (1997). "Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.". EMBO J. 15 (24): 6887–98. PMID 9003765.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.
Cruz M, Elenich LA, Smolarek TA, et al. (1998). "DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene.". Genomics 45 (3): 618–22. doi:10.1006/geno.1997.4977. PMID 9367687.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
Schmidt M, Zantopf D, Kraft R, et al. (1999). "Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex.". J. Mol. Biol. 288 (1): 117–28. doi:10.1006/jmbi.1999.2660. PMID 10329130.
Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835–42. PMID 10436176.
Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419.