PSMB4

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Proteasome (prosome, macropain) subunit, beta type, 4
PDB rendering based on 1iru.
Available structures: 1iru
Identifiers
Symbol(s) PSMB4; HN3; HsN3; PROS26
External IDs OMIM: 602177 MGI: 1098257 HomoloGene: 2090
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5692 19172
Ensembl ENSG00000159377 ENSMUSG00000005779
Uniprot P28070 Q3THC0
Refseq NM_002796 (mRNA)
NP_002787 (protein)		 NM_008945 (mRNA)
NP_032971 (protein)
Location Chr 1: 149.61 - 149.64 Mb Chr 3: 94.97 - 94.97 Mb
Pubmed search [1] [2]

Proteasome (prosome, macropain) subunit, beta type, 4, also known as PSMB4, is a human gene.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.[1]

[edit] References

  1. ^ Entrez Gene: PSMB4 proteasome (prosome, macropain) subunit, beta type, 4.

[edit] Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196. 
  • Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693. 
  • Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667. 
  • Lee LW, Moomaw CR, Orth K, et al. (1990). "Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).". Biochim. Biophys. Acta 1037 (2): 178–85. PMID 2306472. 
  • Kristensen P, Johnsen AH, Uerkvitz W, et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing.". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265. 
  • Nothwang HG, Tamura T, Tanaka K, Ichihara A (1994). "Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.". Biochim. Biophys. Acta 1219 (2): 361–8. PMID 7918633. 
  • Gerards WL, Hop FW, Hendriks IL, Bloemendal H (1994). "Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity.". FEBS Lett. 346 (2-3): 151–5. PMID 8013624. 
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628. 
  • McCusker D, Jones T, Sheer D, Trowsdale J (1998). "Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex.". Genomics 45 (2): 362–7. doi:10.1006/geno.1997.4948. PMID 9344661. 
  • Rossi F, Evstafieva A, Pedrali-Noy G, et al. (1997). "HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein.". Virology 237 (1): 33–45. doi:10.1006/viro.1997.8752. PMID 9344905. 
  • Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770. 
  • Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577. 
  • Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835–42. PMID 10436176. 
  • Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419. 
  • Feng Y, Longo DL, Ferris DK (2001). "Polo-like kinase interacts with proteasomes and regulates their activity.". Cell Growth Differ. 12 (1): 29–37. PMID 11205743. 
  • Lin Y, Martin J, Gruendler C, et al. (2002). "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).". BMC Cell Biol. 3: 15. PMID 12097147. 
  • Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.". Nature 418 (6898): 646–50. doi:10.1038/nature00939. PMID 12167863. 
  • Huang X, Seifert U, Salzmann U, et al. (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.". J. Mol. Biol. 323 (4): 771–82. PMID 12419264. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
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