PSMA1

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) subunit, alpha type, 1

PDB rendering based on 1iru.

Available structures: 1iru

Identifiers

Symbol(s)

PSMA1; HC2; MGC14542; MGC14575; MGC14751; MGC1667; MGC21459; MGC22853; MGC23915; NU; PROS30

External IDs

OMIM: 602854 MGI: 1347005 HomoloGene: 2080

Gene ontology
Molecular Function:	• RNA binding • threonine endopeptidase activity
Cellular Component:	• nucleus • cytosol • proteasome core complex (sensu Eukaryota) • polysome
Biological Process:	• ubiquitin-dependent protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002786 (mRNA)
NP_002777 (protein)

NM_011965 (mRNA)
NP_036095 (protein)

Location

Chr 11: 14.48 - 14.62 Mb

Chr 7: 114.06 - 114.07 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) subunit, alpha type, 1, also known as PSMA1, is a human gene.^[1]

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1.

[edit] Further reading

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693.
Silva Pereira I, Bey F, Coux O, Scherrer K (1992). "Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes.". Gene 120 (2): 235–42. PMID 1398136.
Shimbara N, Orino E, Sone S, et al. (1992). "Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells.". J. Biol. Chem. 267 (25): 18100–9. PMID 1517242.
Kanayama H, Tanaka K, Aki M, et al. (1992). "Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells.". Cancer Res. 51 (24): 6677–85. PMID 1660345.
DeMartino GN, Orth K, McCullough ML, et al. (1991). "The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.". Biochim. Biophys. Acta 1079 (1): 29–38. PMID 1888762.
Tamura T, Lee DH, Osaka F, et al. (1991). "Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).". Biochim. Biophys. Acta 1089 (1): 95–102. PMID 2025653.
Bey F, Silva Pereira I, Coux O, et al. (1993). "The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family.". Mol. Gen. Genet. 237 (1-2): 193–205. PMID 7681138.
Kristensen P, Johnsen AH, Uerkvitz W, et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing.". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.
Gerards WL, de Jong WW, Bloemendal H, Boelens W (1998). "The human proteasomal subunit HsC8 induces ring formation of other alpha-type subunits.". J. Mol. Biol. 275 (1): 113–21. doi:10.1006/jmbi.1997.1429. PMID 9451443.
Tipler CP, Hutchon SP, Hendil K, et al. (1998). "Purification and characterization of 26S proteasomes from human and mouse spermatozoa.". Mol. Hum. Reprod. 3 (12): 1053–60. PMID 9464850.
Henry L, Baz A, Château MT, et al. (1998). "Proteasome (prosome) subunit variations during the differentiation of myeloid U937 cells.". Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 15 (3): 131–44. PMID 9497851.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
Dahlmann B, Kopp F, Kristensen P, Hendil KB (1999). "Identical subunit topographies of human and yeast 20S proteasomes.". Arch. Biochem. Biophys. 363 (2): 296–300. doi:10.1006/abbi.1999.1104. PMID 10068451.
Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835–42. PMID 10436176.
Tanahashi N, Murakami Y, Minami Y, et al. (2000). "Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.". J. Biol. Chem. 275 (19): 14336–45. PMID 10799514.
Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419.