PSIP1

From Wikipedia, the free encyclopedia

PC4 and SFRS1 interacting protein 1

PDB rendering based on 1z9e.

Available structures: 1z9e, 2b4j

Identifiers

Symbol(s)

PSIP1; p75; p52; DFS70; LEDGF; MGC74712; PAIP; PSIP2

External IDs

OMIM: 603620 MGI: 2142116 HomoloGene: 13242

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021144 (mRNA)
NP_066967 (protein)

NM_133948 (mRNA)
NP_598709 (protein)

Location

Chr 9: 15.45 - 15.5 Mb

Chr 4: 82.93 - 82.96 Mb

Pubmed search

[1]

[2]

PC4 and SFRS1 interacting protein 1, also known as PSIP1, is a human gene.^[1] It is thought to impede the replication of HIV.

[edit] References

^ Entrez Gene: PSIP1 PC4 and SFRS1 interacting protein 1.

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Van Maele B, Busschots K, Vandekerckhove L, et al. (2006). "Cellular co-factors of HIV-1 integration.". Trends Biochem. Sci. 31 (2): 98-105. doi:10.1016/j.tibs.2005.12.002. PMID 16403635.
Freed EO, Mouland AJ (2006). "The cell biology of HIV-1 and other retroviruses.". Retrovirology 3: 77. doi:10.1186/1742-4690-3-77. PMID 17083721.
Ge H, Si Y, Roeder RG (1999). "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.". EMBO J. 17 (22): 6723-9. doi:10.1093/emboj/17.22.6723. PMID 9822615.
Ge H, Si Y, Wolffe AP (1999). "A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2.". Mol. Cell 2 (6): 751-9. PMID 9885563.
Singh DP, Ohguro N, Kikuchi T, et al. (2000). "Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts.". Biochem. Biophys. Res. Commun. 267 (1): 373-81. doi:10.1006/bbrc.1999.1979. PMID 10623627.
Singh DP, Kimura A, Chylack LT, Shinohara T (2000). "Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing.". Gene 242 (1-2): 265-73. PMID 10721720.
Ochs RL, Muro Y, Si Y, et al. (2000). "Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1211-20. PMID 10856157.
Kubo E, Fatma N, Sharma P, et al. (2002). "Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF).". J. Mol. Biol. 320 (5): 1053-63. PMID 12126624.
Wu X, Daniels T, Molinaro C, et al. (2003). "Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders.". Cell Death Differ. 9 (9): 915-25. doi:10.1038/sj.cdd.4401063. PMID 12181742.
Cherepanov P, Maertens G, Proost P, et al. (2003). "HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.". J. Biol. Chem. 278 (1): 372-81. doi:10.1074/jbc.M209278200. PMID 12407101.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Maertens G, Cherepanov P, Pluymers W, et al. (2003). "LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.". J. Biol. Chem. 278 (35): 33528-39. doi:10.1074/jbc.M303594200. PMID 12796494.
Maertens G, Cherepanov P, Debyser Z, et al. (2004). "Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.". J. Biol. Chem. 279 (32): 33421-9. doi:10.1074/jbc.M404700200. PMID 15163664.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Llano M, Vanegas M, Fregoso O, et al. (2004). "LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes.". J. Virol. 78 (17): 9524-37. doi:10.1128/JVI.78.17.9524-9537.2004. PMID 15308744.
Cherepanov P, Devroe E, Silver PA, Engelman A (2005). "Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.". J. Biol. Chem. 279 (47): 48883-92. doi:10.1074/jbc.M406307200. PMID 15371438.
Llano M, Delgado S, Vanegas M, Poeschla EM (2005). "Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase.". J. Biol. Chem. 279 (53): 55570-7. doi:10.1074/jbc.M408508200. PMID 15475359.
Ogawa Y, Sugiura K, Watanabe A, et al. (2005). "Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain.". J. Autoimmun. 23 (3): 221-31. doi:10.1016/j.jaut.2004.07.003. PMID 15501393.
Okamoto M, Ogawa Y, Watanabe A, et al. (2005). "Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients.". J. Autoimmun. 23 (3): 257-66. doi:10.1016/j.jaut.2004.07.004. PMID 15501396.