PRSS16

From Wikipedia, the free encyclopedia

Protease, serine, 16 (thymus)

Identifiers

PRSS16; FLJ36271; FLJ40714; FLJ44172; TSSP

External IDs

OMIM: 607169 MGI: 1859181 HomoloGene: 38106

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • serine-type peptidase activity
Cellular Component:	• cellular_component
Biological Process:	• proteolysis • protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005865 (mRNA)
NP_005856 (protein)

NM_019429 (mRNA)
NP_062302 (protein)

Location

Chr 6: 27.32 - 27.33 Mb

Chr 13: 22.01 - 22.02 Mb

Pubmed search

[1]

[2]

Protease, serine, 16 (thymus), also known as PRSS16, is a human gene.^[1]

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRSS16 protease, serine, 16 (thymus).

[edit] Further reading

Lie BA, Viken MK, Akselsen HE, et al. (2007). "Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.". Hum. Immunol. 68 (7): 592-8. doi:10.1016/j.humimm.2007.03.009. PMID 17584581.
Luther C, Wienhold W, Oehlmann R, et al. (2005). "Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus.". Genes Immun. 6 (1): 1-7. doi:10.1038/sj.gene.6364142. PMID 15592422.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Lie BA, Akselsen HE, Bowlus CL, et al. (2003). "Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases.". Genes Immun. 3 (5): 306-12. doi:10.1038/sj.gene.6363858. PMID 12140752.
Bowlus CL, Ahn J, Chu T, Gruen JR (1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus.". Cell. Immunol. 196 (2): 80-6. doi:10.1006/cimm.1999.1543. PMID 10527559.
Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region.". Genomics 36 (1): 70-85. PMID 8812418.