Talk:Propofol

From Wikipedia, the free encyclopedia

This is the talk page for discussing improvements to the Propofol article.
Please sign and date your posts by typing four tildes (~~~~). Put new text under old text. Click here to start a new topic. New to Wikipedia? Welcome! Ask questions, get answers. This is not a forum for general discussion about the article's subject.	Be polite Assume good faith No personal attacks Be welcoming	Article policies No original research Neutral point of view Verifiability

	Propofol is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome.
B	This article has been rated as B-Class on the quality scale.
Mid	This article has been rated as mid-importance for this Project's importance scale.

Advantages of propofol include rapid, clear headed recovery within 5-10 minutes, even after prolonged use, and a reduced incidence of postoperative nausea and vomiting.

{{sofixit}} JFW | T@lk 22:26, 24 July 2005 (UTC)

Is the half-life 30--60 min or 2--24 hr?

30-60 min is the elimination phase halflife, as per product information. Initial (re-distribution) phase halflife = 2-4 min. Ld99 11:35, 11 December 2006 (UTC)

Isn't benzyl alcohol toxic? (Or are they only neurotoxic?) Why would it be used as preservatives? I can't say I've seen such formulations yet. Ld99 11:39, 11 December 2006 (UTC)

Contents 1 Link with Alzheimer's disease 2 Pain on injection 3 Ph-data removal 4 Amnesia Effect 5 Picture

[edit] Link with Alzheimer's disease

This section is totally absurd. This is the kind of preliminary results that make everyday science, it has not been commented (to my knowledge) and hasn't been extensively scrutinized. It can be then considered as not mainstream knowledge. In a scientific review on propofol, this study will take at most one line, if any. Of note, the journal of publication, Neurochemical Research, is absolutely not notorious. I will therefore remove this section. ^talk 02:14, 2 January 2007 (UTC)

[edit] Pain on injection

I hestitate to edit such things, but as a nonprofessional I'm going on what the drugs.com website says, who cites the information provided by the drug manufacturer. I presume they know what they're talking about. --Robert Merkel 02:34, 2 January 2007 (UTC)

[edit] Ph-data removal

I have removed the cited pH range for Diprivan as it was incorrect. In fact there are substantial differences between the pH and properties of Diprivan and some of the propofol generics; to explain these would probably fall outside the scope of the article and get into some detailed wrangling over product claims and intellectual property, which is probably not particularly central to the article.

Astrazenece Scientist, 5/1/07 --—Preceding unsigned comment added by 71.207.34.46 (talk • contribs)

[edit] Amnesia Effect

I'm a little surprised to find that the amnesia effect of propofol isn't mentioned in this article. http://www.anesthesia-analgesia.org/cgi/content/full/91/5/1056?ck=nck and http://bja.oxfordjournals.org/cgi/content/full/89/3/376 and even in Time Magazine, of all places (http://www.time.com/time/health/article/0,8599,1671492,00.html) (Rabagley 16:15, 18 October 2007 (UTC))

The amnestic effect is as great as that from midazolam. Reference added. This article doesn't need to get into the differences between explicit and implicit memory. Essentially propofol when given for sedation also prevents memory storage. The rest is beyond the scope of this article. Mfbabcock (talk) 04:16, 31 March 2008 (UTC)

[edit] Picture

Why does the picture look as though the Propofol is pink? 86.132.164.7 (talk) 10:36, 22 January 2008 (UTC)

Is this perhaps one of the veterinary formulations? All human formulas I've seen are white. Mfbabcock (talk) 03:43, 31 March 2008 (UTC)