Talk:Programmed cell death
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) This article focuses on programmed cell death (PCD) in plants and slime moulds, discusses the evolutionary origins, and has a link to phenoptosis. Its main weaknesses are as follows: 1. In the Introductory first lines it contrasts PCD with necrosis, ignoring the current debate on programmed necrosis. 2. It specifies only 2 main types of PCD. In this it follows the error of Scwartz et al. (1993), who equate autophagic cell death with the "cytoplasmic type", but these two types are very different morphologically, and most researchers consider them to be distinct. Most researchers follow Clarke's (1990) classification into 3, not 2, main types of cell death, according to which apoptosis is type 1, autophagic cell death is type 2, and the cytoplasmic type is type 3B (3A is a rare subtype). 3. The article says nothing about the most widely studied areas of research on PCD including: - vertebrate development; - different types of PCD in cancer therapy; - different types of PCD in various acute diseases including excitotoxicity and stroke, neonatal asphyxia, ischemia of the heart; - neurodegenerative diseases. PGHClarke 12:34, 24 July 2007 (UTC) |
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July 2004: "Programmed cell death" had been, until today, redirected to "Apoptosis". But for some time now, it became more and more necessary to have a separate article on PCD. First, because, PCD and apoptosis are not synonimous (as explained in the new article on PCD). One of the founding figures in the field, Richard Lockshin, has pointed this out repeatedly (see, for instance, Lockshin and Zakeri: "Programmed cell death and apoptosis: origins of the theory", Nature Reviews Molecular Cell Biology, cited in the article), as well as other authors and researchers (see both Schwarz et al.and Bursh et al., as referenced in the article).
Another reason for splitting the apoptosis article is that it was getting too big, at the same time that it was encompassing concepts that did not properly belong there, such as plant PCD. -- jaimeglz
April 2006: I totally agree. I am researching on PCD besides caspase-dependent apoptosis and i am grateful for the separation of apoptosis from PCD. PCD is more than apoptosis and there are diverse regulated pathways for a cell to die ;-). -- lt
December 2007: It needs to talk about recent studies on PCD in bacteria - GASP phenotype, toxin/antidote addiction modules, and possibly the entericidin locus. -- jinkbl0t —Preceding unsigned comment added by 136.152.178.103 (talk) 20:22, 3 December 2007 (UTC)
