Talk:Probenecid

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This is an old drug (1951). I wonder how it was noticed that it delay excretion of therapeutic drugs? Maybe this is some type of purine analogue to help gout sufferers; it helps excrete uric acid. Note that it has some side effects (kidney,liver) but if it hasn't been yanked yet then it's likely got an OK profile. Interestingly, available in China as the ampicillin/probenecid combo, by Chengdu List Pharmaceutical, listpharma.com. If you have expensive ailment it is cheaper to fly to HK or China, buy the medicine OTC, and have a nice holiday on your savings. regford 01:30, 13 September 2006 (UTC) Bold text

72.193.215.135 00:59, 24 September 2007 (UTC) How to make this drug? In stead of using this drug, is there any food has the same effect?

Discussion by 75.162.168.144 moved from article to discussion. "Probenecid's exact mechanism of action in the kidneys' nephrons is unknown. I wish to question this statement. The text Human Physiology by Dee Unglaub Silverthorn explains that gout is caused by elevated levels of uric acid in the plasma, and that the kidney's organic anion transporter (OAT) reclaims uric acid from the urine and returns it to the plasma. If the organic acid probenecid is administered to a patient, the OAT binds to probenecid instead of to uric acid, preventing the reabsorption of uric acid. As a result, more uric acid leaves the body in the urine, lowering the uric acid concentration in the plasma. This is an example of the way in which competition between substrates transported across cell membranes has been put to use in medicine." Can anyone find any more on this? NoQuarter (talk) 00:03, 10 January 2008 (UTC)