Protein N-acetylglucosaminyltransferase

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In enzymology, a protein N-acetylglucosaminyltransferase (EC 2.4.1.94) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + protein $\rightleftharpoons$ UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and protein, whereas its two products are UDP and 4-N-(N-acetyl-D-glucosaminyl)-protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase. Other names in common use include uridine diphosphoacetylglucosamine-protein, acetylglucosaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide, beta-N-acetylglucosaminyltransferase, and O-GlcNAc transferase.

[edit] References

IUBMB entry for 2.4.1.94
BRENDA references for 2.4.1.94 (Recommended.)
PubMed references for 2.4.1.94
PubMed Central references for 2.4.1.94
Google Scholar references for 2.4.1.94
Khalkhall Z, Marshall RD (1975). "Glycosylation of ribonuclease A catalysed by rabbit liver extracts". Biochem. J. 146: 299–307. PMID 1156375.
Khalkhali Z, Marshall RD (1976). "UDP-N-acetyl-D-glucosamine-asparagine sequon N-acetyl-beta-D-glucosaminyl-transferase-activity in human serum". Carbohydr. Res. 49: 455–73. PMID 986874.
Khalkhali Z, Marshall RD, Reuvers F, Habets-Willems C, Boer P (1976). "Glycosylation in vitro of an asparagine sequon catalysed by preparations of yeast cell membranes". Biochem. J. 160: 37–41. PMID 795426.