Protein-histidine N-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a protein-histidine N-methyltransferase (EC 2.1.1.85) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + protein L-histidine S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine

Thus, the two substrates of this enzyme are S-adenosyl methionine and protein L-histidine, whereas its two products are S-adenosylhomocysteine and protein Ntau-methyl-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase. Other names in common use include protein methylase IV, protein (histidine) methyltransferase, actin-specific histidine methyltransferase, and S-adenosyl methionine:protein-histidine N-methyltransferase.

[edit] References

• IUBMB entry for 2.1.1.85
• BRENDA references for 2.1.1.85 (Recommended.)
• PubMed references for 2.1.1.85
• PubMed Central references for 2.1.1.85
• Google Scholar references for 2.1.1.85
• Vijayasarathy C, Rao BS (1987). "Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle". Biochim. Biophys. Acta. 923: 156–65. PMID 3801515. 

[edit] External links

The CAS registry number for this enzyme class is 108022-17-9.

• IUBMB entry for 2.1.1.85

• KEGG entry for 2.1.1.85

• BRENDA entry for 2.1.1.85

• NiceZyme view of 2.1.1.85

• EC2PDB: PDB structures for 2.1.1.85

• PRIAM entry for 2.1.1.85

• PUMA2 entry for 2.1.1.85

• IntEnz: Integrated Enzyme entry for 2.1.1.85

• MetaCyc entry for 2.1.1.85

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018064: protein-histidine N-methyltransferase

• AMIGO entry for GO code 0018064: protein-histidine N-methyltransferase