Protein-glutamine glutaminase

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In enzymology, a protein-glutamine glutaminase (EC 3.5.1.44) is an enzyme that catalyzes the chemical reaction

protein L-glutamine + H₂O protein L-glutamate + NH₃

Thus, the two substrates of this enzyme are protein L-glutamine and H₂O, whereas its two products are protein L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is protein-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase II, glutaminyl-peptide glutaminase, destabilase, and peptidylglutaminase II.

[edit] References

• IUBMB entry for 3.5.1.44
• BRENDA references for 3.5.1.44 (Recommended.)
• PubMed references for 3.5.1.44
• PubMed Central references for 3.5.1.44
• Google Scholar references for 3.5.1.44
• Kikuchi M, Hayashida H, Nakano E, Sakaguchi K (1971). "Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine". Biochemistry. 10: 1222–9. doi:10.1021/bi00783a019. PMID 4928623. 

[edit] External links

The CAS registry number for this enzyme class is 62213-11-0.

• IUBMB entry for 3.5.1.44

• KEGG entry for 3.5.1.44

• BRENDA entry for 3.5.1.44

• NiceZyme view of 3.5.1.44

• EC2PDB: PDB structures for 3.5.1.44

• PRIAM entry for 3.5.1.44

• PUMA2 entry for 3.5.1.44

• IntEnz: Integrated Enzyme entry for 3.5.1.44

• MetaCyc entry for 3.5.1.44

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050568: protein-glutamine glutaminase

• AMIGO entry for GO code 0050568: protein-glutamine glutaminase